872874-00-5
Chemical Structure
SH-053-S-CH3-2'F
- CAS No.: 872874-00-5
- Formula:C23H18FN3O2
- Molecular Weight:387.41
IUPAC Name: ethyl (S)-8-ethynyl-6-(2-fluorophenyl)-4-methyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate
InChIKey: NGYKELBMVXBFSM-AWEZNQCLSA-N
SMILES: O=C(C1=C2N(C=N1)C3=CC=C(C#C)C=C3C(C4=CC=CC=C4F)=N[C@H]2C)OCC
Biological Activity: SH-053-S-CH3-2'F is a selective positive allosteric modulator that produces mild to partial agonistic activity at α(1) GABA(A) receptors. SH-053-S-CH3-2'F showed anxiety-relieving effects at a dose of 30 mg/kg. SH-053-S-CH3-2'F completely avoids the memory impairment commonly caused by benzodiazepine site agonists. SH-053-S-CH3-2'F shows strong selectivity at GABA(A) receptors, which could potentially be used to develop more selective anti-anxiety drugs[1].
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SH-053-S-CH3-2'F | SH-053-S-CH3-2'F is a selective positive allosteric modulator that produces mild to partial agonistic activity at α(1) GABA(A) receptors. SH-053-S-CH3-2'F showed anxiety-relieving effects at a dose of 30 mg/kg. SH-053-S-CH3-2'F completely avoids the memory impairment commonly caused by benzodiazepine site agonists. SH-053-S-CH3-2'F shows strong selectivity at GABA(A) receptors, which could potentially be used to develop more selective anti-anxiety drugs. | |||||||||||||||||||||
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Keywords
