890056-27-6
890056-27-6
Chemical Structure
Custirsen
Synonym(s): OGX-011
- CAS No.: 890056-27-6
- Formula:N/A
- Molecular Weight:7346.00
SMILES: [Custirsen]
Biological Activity: Custirsen (OGX-011) is an antisense oligonucleotide that targets clusterin mRNA. Custirsen induces apoptosis by activating Bax, triggering mitochondrial translocation and cytochrome c release. Custirsen acts as a chemosensitizer, radiosensitizer and hormone sensitizer. Custirsen can be used in research related to prostate cancer, non-small cell lung cancer and metastatic breast cancer[1][2][3].
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Custirsen | 96.06% | Custirsen (OGX-011) is an antisense oligonucleotide that targets clusterin mRNA. Custirsen induces apoptosis by activating Bax, triggering mitochondrial translocation and cytochrome c release. Custirsen acts as a chemosensitizer, radiosensitizer and hormone sensitizer. Custirsen can be used in research related to prostate cancer, non-small cell lung cancer and metastatic breast cancer. | ||||||||||||||||||||
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References
- [1]. Chi KN, et al. A phase I pharmacokinetic and pharmacodynamic study of OGX-011, a 2'-methoxyethyl antisense oligonucleotide to clusterin, in patients with localized prostate cancer. J Natl Cancer Inst. 2005;97(17):1287-1296. [Content Brief]
- [2]. Al-Asaaed S, et al. Custirsen (OGX-011): clusterin inhibitor in metastatic prostate cancer. Curr Oncol Rep. 2013;15(2):113-118. [Content Brief]
- [3]. Chi KN, et al. Custirsen (OGX-011): a second-generation antisense inhibitor of clusterin for the treatment of cancer. Expert Opin Investig Drugs. 2008;17(12):1955-1962. [Content Brief]
Keywords
