909197-38-2
Chemical Structure
NSC-658497
- CAS No.: 909197-38-2
- Formula:C20H10N2O6S2
- Molecular Weight:438.43
IUPAC Name: (Z)-3-((5-((Z)-4-nitrobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)methylene)chromane-2,4-dione
InChIKey: DJFUFNNDOAUACG-FUVGAYRCSA-N
SMILES: O=C1/C(C(C2=CC=CC=C2O1)=O)=C\N3C(S/C(C3=O)=C\C4=CC=C([N+]([O-])=O)C=C4)=S
Biological Activity: NSC-658497 is an effective inhibitor of Ras-GEF, SOS1. NSC-658497 binds to SOS1, competitively suppresses SOS1-Ras interaction, and dose-dependently inhibits SOS1 GEF activity. NSC-658497 showed dose-dependent efficacy in inhibiting Ras, downstream signaling activities, and associated cell proliferation[1].
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NSC-658497 | NSC-658497 is an effective inhibitor of Ras-GEF, SOS1. NSC-658497 binds to SOS1, competitively suppresses SOS1-Ras interaction, and dose-dependently inhibits SOS1 GEF activity. NSC-658497 showed dose-dependent efficacy in inhibiting Ras, downstream signaling activities, and associated cell proliferation. | |||||||||||||||||||||
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Keywords
