911714-45-9
911714-45-9
Chemical Structure
Petadeferitrin
Synonym(s): SP-420
- CAS No.: 911714-45-9
- Formula:C16H21NO6S
- Molecular Weight:355.41
IUPAC Name: (S)-2-(2-hydroxy-4-(2-(2-methoxyethoxy)ethoxy)phenyl)-4-methyl-4,5-dihydrothiazole-4-carboxylic acid
InChIKey: YASYAEVZKXPYIZ-MRXNPFEDSA-N
SMILES: O=C([C@]1(C)N=C(C2=CC=C(OCCOCCOC)C=C2O)SC1)O
Biological Activity: Petadeferitrin (SP-420) is a tridentate iron chelator belonging to the class of iron chelators, with orally activity. Petadeferitrin can be used in research related to β-thalassemia[1][2][3].
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Petadeferitrin | 99.71% | Petadeferitrin (SP-420) is a tridentate iron chelator belonging to the class of iron chelators, with orally activity. Petadeferitrin can be used in research related to β-thalassemia. | ||||||||||||||||||||
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References
- [1]. Bergeron RJ, et al. Substituent effects on desferrithiocin and desferrithiocin analogue iron-clearing and toxicity profiles. J Med Chem. 2012 Aug 23;55(16):7090-103. [Content Brief]
- [2]. Basu S, et al. Understanding the intricacies of iron overload associated with β-thalassemia: a comprehensive review[J]. Thalassemia Reports, 2023, 13(3): 179-194.
- [3]. Taher A T, et al. Safety and pharmacokinetics of the oral iron chelator SP‐420 in β‐thalassemia[J]. American Journal of Hematology, 2017, 92(12): 1356-1361. [Content Brief]
Keywords
