924636-93-1
924636-93-1
Chemical Structure
AF3442
- CAS No.: 924636-93-1
- Formula:C22H17F3N2O
- Molecular Weight:382.38
IUPAC Name: N-(9-ethyl-9H-carbazol-3-yl)-2-(trifluoromethyl)benzamide
InChIKey: GHLDHBQXNPNZEI-UHFFFAOYSA-N
SMILES: O=C(NC1=CC2=C(C=C1)N(CC)C3=C2C=CC=C3)C4=CC=CC=C4C(F)(F)F
Biological Activity: AF3442 is a potent and selective mPGES-1 inhibitor (IC50 = 0.06 μM) which reduces monocyte PGE2 generation also in the presence of plasma proteins. AF3442 shows selectivity over other prostanoids (TXB2, PGF2α and 6-keto-PGF1α). AF3442 can be used for research in analgesia[1].
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AF3442 | AF3442 is a potent and selective mPGES-1 inhibitor (IC50 = 0.06 μM) which reduces monocyte PGE2 generation also in the presence of plasma proteins. AF3442 shows selectivity over other prostanoids (TXB2, PGF2α and 6-keto-PGF1α). AF3442 can be used for research in analgesia. | |||||||||||||||||||||
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References
Keywords
