925218-37-7
925218-37-7
Chemical Structure
AKI-001
- CAS No.: 925218-37-7
- Formula:C21H24N4O
- Molecular Weight:348.44
IUPAC Name: 8-ethyl-3,10,10-trimethyl-4,5,6,8,10,12-hexahydropyrazolo[4',3':6,7]cyclohepta[1,2-b]pyrrolo[2,3-f]indol-9(2H)-one
InChIKey: AOMMPEGZDRAGRC-UHFFFAOYSA-N
SMILES: O=C1C(C)(C)C2=CC3=C(C=C2N1CC)C(CCCC4=C(C)NN=C45)=C5N3
Biological Activity: AKI-001 is an prototype pentacyclic inhibitor of aurora kinase with cellular potency of IC50 of less than 100 nM. AKI-001 shows low nanomolar potency against Aurora A and Aurora B enzymes[1].
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AKI-001 | AKI-001 is an prototype pentacyclic inhibitor of aurora kinase with cellular potency of IC50 of less than 100 nM. AKI-001 shows low nanomolar potency against Aurora A and Aurora B enzymes. | |||||||||||||||||||||
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References
Keywords
