92692-39-2
92692-39-2
Chemical Structure
Amorphadiene
- CAS No.: 92692-39-2
- Formula:C15H24
- Molecular Weight:204.35
IUPAC Name: (1R,4R,4aS,8aR)-4,7-dimethyl-1-(prop-1-en-2-yl)-1,2,3,4,4a,5,6,8a-octahydronaphthalene
InChIKey: HMTAHNDPLDKYJT-CBBWQLFWSA-N
SMILES: CC([C@H]1[C@]2([H])[C@](CCC(C)=C2)([H])[C@@H](CC1)C)=C
Biological Activity: Amorphadiene is the precursor to the antimalarial agent artemisinin, which is produced through the amorphadiene synthase (ADS)-catalyzed cyclization of farnesyl pyrophosphate (FPP) yeast[1][2].
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Amorphadiene | Amorphadiene is the precursor to the antimalarial agent artemisinin, which is produced through the amorphadiene synthase (ADS)-catalyzed cyclization of farnesyl pyrophosphate (FPP) yeast. | |||||||||||||||||||||
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References
- [1]. Westfall PJ, et al. Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin. Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):E111-8. [Content Brief]
- [2]. Pramastya H, et al. High level production of amorphadiene using Bacillus subtilis as an optimized terpenoid cell factory. N Biotechnol. 2021 Jan 25;60:159-167. [Content Brief]
Keywords
