928023-21-6
928023-21-6
Chemical Structure
PPARδ agonist 9
- CAS No.: 928023-21-6
- Formula:C26H28ClF3N4O3S
- Molecular Weight:569.04
InChIKey: KAGLXEKIFXHEMB-UHFFFAOYSA-N
SMILES: ClC1=CC(CC(O)=O)=CC(OCCC2(N3CCCC3)CCN(C4=NC5=CC=C(N=C5S4)C(F)(F)F)CC2)=C1
Biological Activity: PPARδ agonist 9 (compound 21) is a PPARδ agonist (EC50: 3.6 nM). PPARδ agonist 9 has in vivo efficacy, reducing serum levels of MCP-1 in mice and significantly inhibiting atherosclerosis progression in the LDLr-KO model (inhibition rate: 50-60%)[1].
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PPARδ agonist 9 | PPARδ agonist 9 (compound 21) is a PPARδ agonist (EC50: 3.6 nM). PPARδ agonist 9 has in vivo efficacy, reducing serum levels of MCP-1 in mice and significantly inhibiting atherosclerosis progression in the LDLr-KO model (inhibition rate: 50-60%). | |||||||||||||||||||||
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References
Keywords
