936091-14-4
936091-14-4
Chemical Structure
TG101209
- CAS No.: 936091-14-4
- Formula:C26H35N7O2S
- Molecular Weight:509.67
IUPAC Name: N-(tert-butyl)-3-((5-methyl-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)benzenesulfonamide
InChIKey: JVDOKQYTTYUYDV-UHFFFAOYSA-N
SMILES: O=S(C1=CC=CC(NC2=NC(NC3=CC=C(C=C3)N4CCN(CC4)C)=NC=C2C)=C1)(NC(C)(C)C)=O
Biological Activity: TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM, less potent to Flt3 and RET with IC50 of 25 nM and 17 nM, appr 30-fold selective for JAK2 than JAK3, and sensitive to JAK2V617F and MPLW515L/K mutations.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TG101209 | 98.13% | TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM, less potent to Flt3 and RET with IC50 of 25 nM and 17 nM, appr 30-fold selective for JAK2 than JAK3, and sensitive to JAK2V617F and MPLW515L/K mutations. | ||||||||||||||||||||
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TG101209 (Standard) | ≥98% | TG101209 (Standard) is the analytical standard of TG101209 (HY-10410). This product is intended for research and analytical applications. TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM, less potent to Flt3 and RET with IC50 of 25 nM and 17 nM, appr 30-fold selective for JAK2 than JAK3, and sensitive to JAK2V617F and MPLW515L/K mutations. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.77
HY-18301JAK-IN-35 -
Similarity Score 0.75
HY-10409Fedratinib -
Similarity Score 0.74
HY-162031MMT3-72-M2 -
Similarity Score 0.74
HY-10409AFedratinib hydrochloride hydrate -
Similarity Score 0.72
HY-14986JAK-IN-32 -
Similarity Score 0.69
HY-115541BRD4-IN-41 -
Similarity Score 0.67
HY-149283JAK/HDAC-IN-2 -
Similarity Score 0.66
HY-172089TG101209 analog 1 -
Similarity Score 0.66
HY-117398HCI-2184 -
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