Cinitapride monotartrate
Cinitapride monotartrate is a 5-HT1A and 5-HT4 agonist. Cinitapride monotartrate is also a 5-HT2A and D2 antagonist. Cinitapride monotartrate can be used for the research of functional dyspepsia.
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- CAS. Nr.: 1207859-16-2
- Formel: C25H36N4O10
- Molecular Weight:552.57
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Alle 5-HT Receptor Isoform-spezifische Produkte anzeigen
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Biologische Aktivität
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5-HT1A Receptor |
5-HT2A Receptor |
5-HT2 Receptor |
5-HT1 Receptor |
5-HT4 Receptor |
D2 Receptor |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats with gastric ulceration[2]
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Dosage:0.25-1 mg/kg
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Administration:Intraperitoneal injection; 0.25-1 mg/kg; once
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Result:Reduced haemorrhagic lesions compared with the ulcerated control group.
Decreased the percentage of ulceration to 28.76% at the highest dose (1 mg/kg).
Attenuated the increase myeloperoxidase activity (p<0.05, p<0.01).
Increased GSH-px activity in the gastric mucosa.
Chemical Information
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CAS. Nr. 1207859-16-2
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Molecular Weight 552.57
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Formel C25H36N4O10
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SMILES
O=C(NC1CCN(CC2CC=CCC2)CC1)C3=CC([N+]([O-])=O)=C(N)C=C3OCC.O=C(O)[C@H](O)[C@@H](O)C(O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Du Y, et al. Efficacy and safety of cinitapride in the treatment of mild to moderate postprandial distress syndrome-predominant functional dyspepsia. J Clin Gastroenterol. 2014 Apr;48(4):328-35. [Content Brief]
[2]. Alarcón de la Lastra C, et al. Effects of cinitapride on gastric ulceration and secretion in rats. Inflamm Res. 1998 Mar;47(3):131-6. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Cinitapride monotartrate Related Classifications
HY-128386 Related Classifications
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