AGPAT1 - 1-acylglycerol-3-phosphate O-acyltransferase 1 Gene

Also Known as G15; LPAATA; LPLAT1; 1-AGPAT1; LPAAT-alpha

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10554

About AGPAT1

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:32,168,212-32,178,108 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 139 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 25.5), brain (RPKM 21.6) and 25 other tissues.

Summary

This gene encodes an enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). LPA and PA are two Phospholipids involved in signal transduction and in lipid biosynthesis in cells. This enzyme localizes to the endoplasmic reticulum. This gene is located in the class III region of the human major histocompatibility complex. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

AGPAT1 Products (5)

mRNA Protein Name
NM_001371437.1 NP_001358366.1 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 2
NM_001371438.1 NP_001358367.1 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 1 precursor
NM_001371439.1 NP_001358368.1 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 1 precursor
NM_006411.4 NP_006402.1 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 1 precursor
NM_032741.5 NP_116130.2 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables 1-acylglycerol-3-phosphate O-acyltransferase activity IDA
IDA: Inferred from direct assay
9461603 GOA
enables 1-acylglycerol-3-phosphate O-acyltransferase activity IGI
IGI: Inferred from genetic interaction
9212163 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in phosphatidic acid biosynthetic process IGI
IGI: Inferred from genetic interaction
9212163 GOA
involved in positive regulation of cytokine production IMP
IMP: Inferred from mutant phenotype
9212163 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
9461603 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AGPAT1 Protein Structure

Acyltransferase

Acyltransferase: Acyltransferase (83 - 211)

  • 0
  • 100
  • 200
  • 283 a.a.
Protein Preferred Names Protein Names

1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

  • 1-AGP acyltransferase 1

AGPAT1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
AGPAT1 Q99943 MEOX2 Homo sapiens P50222
Y2H Array
25416956
Intra
AGPAT1 Q99943 RNASEH2A Homo sapiens O75792
Anti Tag CoIP
33961781
Intra
AGPAT1 Q99943 RNASEH2A Homo sapiens O75792
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Lipodystrophy, Congenital Generalized, Type 1

  • Congenital Generalized Lipodystrophy Type 1

  • Bscl1

  • CGL1

  • Berardinelli-Seip Congenital Lipodystrophy, Type 1

  • Brunzell Syndrome Agpat2-Related

  • Berardinelli-Seip Congenital Lipodystrophy Type 1

  • Lipodystrophy, Berardinelli-Seip Congenital, Type 1

  • Brunzell Syndrome, Agpat2-Related

  • Agpat2-Related Brunzell Syndrome

  • Congenital Generalized Lipodystrophy 1

  • Berardinelli-Seip Syndrome

  • Lipoatrophic Diabetes

  • Lipodystrophy Berardinelli Type

  • Total Lipodystrophy And Acromegaloid Gigantism

  • Lipodystrophy, Generalized, Congenital, Type 1

  • Familial Generalized Lipodystrophy

  • Lipoatrophic Diabetes Mellitus

  • Familial Partial Lipodystrophy, Type 2
Complete Generalized Lipodystrophy
Lipodystrophy, Congenital Generalized, Type 2

  • Congenital Generalized Lipodystrophy Type 2

  • CGL2

  • Berardinelli-Seip Congenital Lipodystrophy Type 2

  • Berardinelli-Seip Syndrome

  • Brunzell Syndrome Bscl2-Related

  • Total Lipodystrophy And Acromegaloid Gigantism

  • Berardinelli-Seip Congenital Lipodystrophy, Type 2

  • Seip Syndrome

  • Berardinelli Syndrome

  • Lipodystrophy, Total, And Acromegaloid Gigantism

  • Lipoatrophic Diabetes, Congenital

  • Lipodystrophy, Berardinelli-Seip Congenital, Type 2

  • Brunzell Syndrome, Bscl2-Related

  • Congenital Lipoatrophic Diabetes

  • Congenital Generalized Lipodystrophy 2

  • Lipoatrophic Diabetes

  • Lipodystrophy Berardinelli Type

  • Familial Generalized Lipodystrophy

  • Lipoatrophic Diabetes Mellitus

  • Familial Partial Lipodystrophy, Type 2
Congenital Generalized Lipodystrophy

  • Berardinelli-Seip Congenital Lipodystrophy

  • Berardinelli-Seip Syndrome

  • Brunzell Syndrome

  • Bscl

  • Generalized Lipodystrophy

  • Lipodystrophy, Congenital Generalized

  • Seip Syndrome

  • Total Lipodystrophy

  • Cgl

  • Lipoatrophic Diabetes

  • Lipodystrophy, Generalized, Congenital

  • Familial Generalized Lipodystrophy

  • Congenital Generalized Lipodystrophy Type 2

  • Lipoatrophic Diabetes Mellitus

  • Familial Partial Lipodystrophy, Type 2
Fetal Akinesia Deformation Sequence 1

  • Fetal Akinesia Deformation Sequence

  • Fads

  • Fetal Akinesia Sequence

  • FADS1

  • Arthrogryposis Multiplex Congenita With Pulmonary Hypoplasia

  • Pena-Shokeir Syndrome Type 1

  • Fetal Akinesia Deformation Sequence Syndrome

  • Arthrogryposis Multiplex Congenita-Pulmonary Hypoplasia Syndrome

  • Arthrogryposis Multiplex Congenita Pulmonary Hypoplasia

  • Pena-Shokeir Syndrome, Type I

  • Foetal Akinesia Deformation Sequence Syndrome

  • Foetal Akinesia Sequence

  • Fetal Akinesia Deformation Sequence Syndrome 1

  • Pena-Shokeir Syndrome, Type 1

  • Pena Shokeir Syndrome, Type 1

  • Akinesia, Fetal, Deformation Sequence

  • Akinesia, Fetal, Deformation Sequence, Type 1

  • Pena-Shokeir Syndrome Type I
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS00456 AGPAT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus AGPAT1 VGNC VGNC:25734
Mus musculus AGPAT1 MGD MGI:1932075
Canis familiaris AGPAT1 VGNC VGNC:37710
Felis catus AGPAT1 VGNC VGNC:102377
Macaca mulatta AGPAT1 VGNC VGNC:69745
Rattus norvegicus AGPAT1 RGD RGD:1303287
Others AGPAT1 NCBI