CTHRC1 - collagen triple helix repeat containing 1 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 115908

About CTHRC1

Cytogenetic location: 8q22.3 Genomic coordinates (GRCh38): 8:103,371,538-103,382,989 (from NCBI)

This gene has 4 transcripts (splice variants), 231 orthologues, 2 paralogues and is associated with 1 phenotype. Biased expression in gall bladder (RPKM 34.5), urinary bladder (RPKM 33.4) and 12 other tissues.

Summary

This locus encodes a protein that may play a role in the cellular response to arterial injury through involvement in vascular remodeling. Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]

CTHRC1 Products (2)

mRNA Protein Name
NM_001256099.2 NP_001243028.1 collagen triple helix repeat-containing protein 1 isoform 2
NM_138455.4 NP_612464.1 collagen triple helix repeat-containing protein 1 isoform 1 precursor

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence Verweise Source
located in extracellular space IDA
IDA: Inferred from direct assay
18467647 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CTHRC1 Protein Structure

Collagen

Collagen: Collagen triple helix repeat (20 copies) (58 - 91)

  • 0
  • 100
  • 200
  • 243 a.a.
Protein Preferred Names Protein Names

collagen triple helix repeat-containing protein 1

Recombinant CTHRC1 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P70092 CTHRC1 Protein, Human (HEK293, His) Q96CG8-1 (S31-K243) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Barrett Esophagus

  • Barrett'S Esophagus

  • Barrett Esophagus/Esophageal Adenocarcinoma

  • Barrett Metaplasia

  • Barrett'S Ulcer Of Esophagus

  • Ulcerative Esophagitis

  • Barrett'S Esophagus With Esophagitis

  • Barrett'S Oesophagus

  • Barretts Syndrome

  • Barrett Syndrome

  • BE

  • Peptic Ulcer Of Esophagus

  • Adenocarcinoma Of Esophagus
Adenocarcinoma

  • Adenocarcinomas

  • Adenoacanthoma Of Unspecified Site

  • Adenocarcinoid Of Unspecified Site

  • Adenocarcinoid Tumour Of Unspecified Site

  • Adenocarcinoma And Carcinoid Combined Of Unspecified Site

  • Adenocarcinoma Nos
Bronchiectasis 1
Gastroesophageal Reflux

  • Gastroesophageal Reflux Disease

  • Gerd

  • GER

  • Gastroesophageal Reflux, Pediatric

  • Acid Reflux

  • Gastresophageal Reflux

  • Gastro-Esophageal Reflux

  • Gerd - Gastro-Esophageal Reflux Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS17347 Cthrc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23801 Cthrc1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03297 CTHRC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CTHRC1 MGD MGI:1915838
Rattus norvegicus CTHRC1 RGD RGD:628801
Macaca mulatta CTHRC1 VGNC VGNC:71436
Felis catus CTHRC1 VGNC VGNC:61251
Bos taurus CTHRC1 VGNC VGNC:27796
Canis familiaris CTHRC1 VGNC VGNC:49728
Others CTHRC1 NCBI