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Mapk8ip3 - mitogen-activated protein kinase 8 interacting protein 3 Gene

Also Known as Jip3; Syd2; JIP-3; JSAP1; JSAP1a; JSAP1b; JSAP1c; JSAP1d; D17Wsu15e; mKIAA1066

Species: Mus musculus

Gene Type: protein coding

Gene ID: 30957

Summary

Enables MAP-kinase scaffold activity; Kinesin binding activity; and protein kinase binding activity. Involved in several processes, including anterograde axonal protein transport; positive regulation of neuron migration; and regulation of MAPK cascade. Acts upstream of or within several processes, including JNK cascade; lung development; and nervous system development. Located in several cellular components, including Golgi membrane; axolemma; and smooth endoplasmic reticulum. Is expressed in several structures, including brain; extraembryonic component; genitourinary system; lung; and spinal cord. Orthologous to human MAPK8IP3 (mitogen-activated protein kinase 8 interacting protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Mapk8ip3 Products (7)

mRNA	Protein	Name
NM_001163447.1	NP_001156919.1	C-Jun-amino-terminal kinase-interacting protein 3 isoform b
NM_001163448.1	NP_001156920.1	C-Jun-amino-terminal kinase-interacting protein 3 isoform c
NM_001163449.1	NP_001156921.1	C-Jun-amino-terminal kinase-interacting protein 3 isoform d
NM_001163450.1	NP_001156922.1	C-Jun-amino-terminal kinase-interacting protein 3 isoform e
NM_001163451.1	NP_001156923.1	C-Jun-amino-terminal kinase-interacting protein 3 isoform f
NM_001163453.1	NP_001156925.1	C-Jun-amino-terminal kinase-interacting protein 3 isoform g
NM_013931.4	NP_038959.2	C-Jun-amino-terminal kinase-interacting protein 3 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables JUN kinase binding	IPI IPI: Inferred from physical interaction	10523642	MGI
enables MAP-kinase scaffold activity	IDA IDA: Inferred from direct assay	10523642	MGI
enables MAP-kinase scaffold activity	IPI IPI: Inferred from physical interaction	10629060	MGI
enables kinesin binding	IDA IDA: Inferred from direct assay	25944905	MGI
enables kinesin binding	IPI IPI: Inferred from physical interaction	10629060	MGI
enables mitogen-activated protein kinase kinase binding	IPI IPI: Inferred from physical interaction	10523642	MGI
enables mitogen-activated protein kinase kinase kinase binding	IPI IPI: Inferred from physical interaction	10523642	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10523642	MGI

Biological Process GO Annotation	Evidence	Verweise	Source
acts upstream of or within JNK cascade	IDA IDA: Inferred from direct assay	10629060	MGI
involved in anterograde axonal protein transport	IMP IMP: Inferred from mutant phenotype	28259553	MGI
involved in axon development	IMP IMP: Inferred from mutant phenotype	23576431	MGI
acts upstream of or within axon guidance	IMP IMP: Inferred from mutant phenotype	15572149	MGI
acts upstream of or within forebrain development	IMP IMP: Inferred from mutant phenotype	12897243	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	18324732	MGI
acts upstream of or within lung alveolus development	IMP IMP: Inferred from mutant phenotype	18324732	MGI
acts upstream of or within lung morphogenesis	IMP IMP: Inferred from mutant phenotype	18324732	MGI
acts upstream of or within positive regulation of JUN kinase activity	IDA IDA: Inferred from direct assay	15767678	MGI
involved in positive regulation of JUN kinase activity	IDA IDA: Inferred from direct assay	10523642	MGI
involved in positive regulation of neuron migration	IMP IMP: Inferred from mutant phenotype	28259553	MGI
acts upstream of or within post-embryonic development	IMP IMP: Inferred from mutant phenotype	18324732	MGI
acts upstream of or within protein localization	IMP IMP: Inferred from mutant phenotype	15572149	MGI
involved in regulation of JNK cascade	IDA IDA: Inferred from direct assay	10629060	MGI
acts upstream of or within regulation of gene expression	IDA IDA: Inferred from direct assay	18324732	MGI
acts upstream of or within respiratory gaseous exchange by respiratory system	IMP IMP: Inferred from mutant phenotype	12897243	MGI
involved in vesicle-mediated transport	IDA IDA: Inferred from direct assay	11106729	MGI

Cellular Component GO Annotation	Evidence	Verweise	Source
located in Golgi membrane	IDA IDA: Inferred from direct assay	11106729	MGI
located in axolemma	IDA IDA: Inferred from direct assay	16606357	MGI
located in axon	IDA IDA: Inferred from direct assay	25944905	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	10523642	MGI
located in dendrite	IDA IDA: Inferred from direct assay	16606357	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	16606357	MGI
located in smooth endoplasmic reticulum	IDA IDA: Inferred from direct assay	16606357	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
C-Jun-amino-terminal kinase-interacting protein 3	JNK MAP kinase scaffold protein 3 JNK-interacting protein 3 JNK/SAPK-associated protein 1 JNK/SAPK-associated protein 1c JUN/SAPK-associated protein 1 c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1 sunday driver

Mapk8ip3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	Mapk8ip3	Q9ESN9	Kif5c	Mus musculus	P28738	Pull Down	21750526
Intra	Mapk8ip3	Q9ESN9	Klc1	Mus musculus	O88447	CoIP	11106729
Intra	Mapk8ip3	Q9ESN9	Klc1	Mus musculus	O88447	Pull Down	11106729
Intra	Mapk8ip3	Q9ESN9	Klc1	Mus musculus	O88447	Pull Down	21750526
Intra	Mapk8ip3	Q9ESN9	Klc2	Mus musculus	O88448	Pull Down	11106729
Intra	Mapk8ip3	Q9ESN9	Klc2	Mus musculus	O88448	CoIP	11106729
Intra	Mapk8ip3	Q9ESN9	Klc2	Mus musculus	O88448	Pull Down	21750526
Intra	Mapk8ip3	Q9ESN9	Arf6	Mus musculus	P62331	Anti Tag CoIP	20493856
Intra	Mapk8ip3	Q9ESN9	Arf6	Mus musculus	P62331	Pull Down	20493856

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS08126	MAPK8IP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mapk8ip3	NCBI	NCBI:23162