Kif5c - kinesin family member 5C Gene

Also Known as Khc; KINN; NKHC; NKHC2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16574

Summary

Predicted to enable several functions, including ATP hydrolysis activity; Apolipoprotein receptor binding activity; and plus-end-directed microtubule motor activity. Involved in mRNA transport. Acts upstream of or within motor neuron axon guidance. Located in several cellular components, including axonal growth cone; ciliary rootlet; and neuronal cell body. Is expressed in several structures, including genitourinary system; nervous system; nose; and retina. Human ortholog(s) of this gene implicated in complex cortical dysplasia with Other brain malformations 2 and schizophrenia. Orthologous to human KIF5C (Kinesin family member 5C). [provided by Alliance of Genome Resources, Apr 2022]

Kif5c Products (1)

mRNA Protein Name
NM_008449.3 NP_032475.2 kinesin heavy chain isoform 5C

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10602484 MGI
Biological Process GO Annotation Evidence References Source
involved in anterograde dendritic transport of messenger ribonucleoprotein complex IDA
IDA: Inferred from direct assay
34260917 MGI
involved in anterograde dendritic transport of messenger ribonucleoprotein complex IMP
IMP: Inferred from mutant phenotype
34260917 MGI
involved in mRNA transport IMP
IMP: Inferred from mutant phenotype
19608740 MGI
acts upstream of or within motor neuron axon guidance IMP
IMP: Inferred from mutant phenotype
10964943 MGI
Cellular Component GO Annotation Evidence References Source
located in axonal growth cone IDA
IDA: Inferred from direct assay
24286867 MGI
located in ciliary rootlet IDA
IDA: Inferred from direct assay
16018997 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
16018997 MGI
located in distal axon IDA
IDA: Inferred from direct assay
24286867 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
16301330 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
24286867 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

kinesin heavy chain isoform 5C

  • kinesin heavy chain member 5C

  • kinesin heavy chain neuron-specific 2

  • kinesin-1

Kif5c Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Kif5c P28738 Mapk8ip3 Mus musculus Q9ESN9
Pull Down
21750526
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07291 KIF5C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22598 Kif5c Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29115 Kif5c Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kif5c NCBI NCBI:3800