Notch3 - notch receptor 3 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 56761

Summary

Predicted to enable enzyme binding activity; identical protein binding activity; and signaling receptor activity. Involved in several processes, including Notch signaling pathway; tissue regeneration; and wound healing. Predicted to be located in actin cytoskeleton; cytosol; and nucleoplasm. Predicted to be part of receptor complex. Predicted to be active in cell surface and plasma membrane. Human ortholog(s) of this gene implicated in CADASIL 1; infantile myofibromatosis; and lateral meningocele syndrome. Orthologous to human NOTCH3 (Notch receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Notch3 Products (1)

mRNA Protein Name
NM_020087.3 NP_064472.3 neurogenic locus notch homolog protein 3 precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence Verweise Source
involved in Notch signaling pathway IDA
IDA: Inferred from direct assay
11925448 RGD
involved in regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11971902 RGD
involved in tissue regeneration IEP
IEP: Inferred from expression pattern
16118793 RGD
involved in wound healing IEP
IEP: Inferred from expression pattern
11549580 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neurogenic locus notch homolog protein 3

  • Notch gene homolog 3

  • notch 3

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-15670 BMS-906024 Inhibitor 99.91% Phase 1
HY-12860 BMS-986115 Inhibitor 99.90% Phase 1
Inhibitory Antibodies (1)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-P99320 Tarextumab Inhibitor 99.83% Phase 2

Pre-clinical Phase

Bioactive Molecules (6)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-15827 NSC 405020 Inhibitor 99.63% Unkown
HY-136522 S2116 98.05% Unkown
HY-RS09451 NOTCH3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-136523 S2157 98.44% Unkown
HY-RS17213 Notch3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23665 Notch3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-P992438 PF-06650808 Antibidy Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Notch3 NCBI NCBI:4854