PF-06650808 Antibidy (Synonyms: Anti-Notch3 mAb hu28)

Cat. No.: HY-P992438: Ficha de datos
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PF-06650808 Antibody (Anti-NOTCH3 mAb hu28) is an IgG1-kappa Notch3-targeting antibody. PF-06650808 Antibody is the antibody component of the antibody-drug conjugate (ADC) PF-06650808. PF-06650808 Antibody can be used for the research of advanced breast cancer, advanced solid tumors.

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PF-06650808 Antibidy Estructura química

Tamaño		Stock
MOQ		Minimum order quantity
1 mg		Obtener un presupuesto
5 mg		Obtener un presupuesto
10 mg		Obtener un presupuesto
Other size		Obtener un presupuesto

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Descripciòn	PF-06650808 Antibody (Anti-NOTCH3 mAb hu28) is an IgG1-kappa Notch3-targeting antibody. PF-06650808 Antibody is the antibody component of the antibody-drug conjugate (ADC) PF-06650808. PF-06650808 Antibody can be used for the research of advanced breast cancer, advanced solid tumors^[1].
Species Reactivity	Human
Gene ID	4854 [NCBI]
Accession	Q9UM47
Target	NOTCH3
Application	ELISA, FACS, Functional assay
Conjugated	Unconjugated
Reconsititution	The product can be reconstituted/diluted with sterile PBS or saline.
Formulation	Please refer to the lot-specific COA for specific buffer information.
Almacenamiento	Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación	Ficha de datos (255 KB) Inhibitory Antibodies User Guide (603 KB)
Referencias	[1]. Rosen LS, et al. A phase I, dose-escalation study of PF-06650808, an anti-Notch3 antibody-drug conjugate, in patients with breast cancer and other advanced solid tumors. Invest New Drugs. 2020;38(1):120-130.

PF-06650808 Antibidy Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-06650808 AntibidyAnti-Notch3 mAb hu28NotchNotch3auristatincynomolgus monkeyscell cycle arrestcarboplatin-resistant ovarian cancertumor cellsapoptosiscisplatin-resistant non-small-cell lung cancertubulintriple-negative breast cancerInhibitorinhibitorinhibit

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PF-06650808 Antibidy (Synonyms: Anti-Notch3 mAb hu28)

PF-06650808 Antibidy Related Antibodies

Recomendaciones destacadas

•Related Small Molecules:

•Related Proteins:

Actividad biológica

Pureza y Documentación

Referencias

Revisión del cliente

PF-06650808 Antibidy Related Classifications

Calculadora de molaridad

Calculadora de dilución