HDAC6-IN-36
HDAC6-IN-36 (compound 11d) is an inhibitor of HDAC6 with IC50 value of 8.64 nM. HDAC6-IN-36 induces neurite outgrowth of PC12 cells without producing toxic effects.
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- Formel: C30H29ClN4O3
- Molecular Weight:529.03
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
Biologische Aktivität
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HDAC1 1284 nM (IC50) |
HDAC6 8.64 nM (IC50) |
HDAC6-IN-36 (1 μM, 24 h) increases the acetylation level of histone H3 and ɑ-tubulin in the PC12 cell line.
HDAC6-IN-36 (1-10 μM, 48 h) stimulates neurite outgrowth induced by NGF (20 ng/mL) in PC12 cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC12 cell
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Concentration:0.1, 0.5 and 1 μM
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Incubation Time:24 h
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Result:Increased the acetylation level of α-tubulin in a dose-dependent manner.
Chemical Information
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Molecular Weight 529.03
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Formel C30H29ClN4O3
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SMILES
O=C(NCC1=CC=C(C(NO)=O)C=C1)[C@H](C2)N(CC3CC3)[C@H](C4=CC=C(Cl)C=C4)C5=C2C6=CC=CC=C6N5
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
HDAC6-IN-36 Related Classifications
HY-162330 Related Classifications
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