Kainic acid hydrate
Based on 41 publication(s) in Google Scholar
Kainic acid hydrate is a potent excitotoxic agent. Kainic acid hydrate also is an agonist for a subtype of ionotropic glutamate receptor. Kainic acid hydrate induces seizures.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.6%
- CAS. Nr.: 58002-62-3
- Formel: C10H17NO5
- Molecular Weight:231.25
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Speicherung:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Publications Citing Use of MedChemExpress (MCE) Kainic acid hydrate
More- Nat Neurosci. 2025 Jul;28(7):1404-1417. [Abstract]
- Nat Neurosci. 2023 Apr;26(4):542-554. [Abstract]
- Neuron. 2025 Aug 27:S0896-6273(25)00591-4. [Abstract]
- Nat Chem Biol. 2024 Dec;20(12):1586-1596. [Abstract]
- J Nanobiotechnology. 2025 May 5;23(1):332. [Abstract]
- Theranostics. 2024 Oct 7;14(16):6373-6391. [Abstract]
- Adv Sci (Weinh). 2026 Jan 28:e19642. [Abstract]
- Adv Sci (Weinh). 2025 Sep 14:e00402. [Abstract]
- Adv Sci (Weinh). 2025 Aug 29:e08161. [Abstract]
- J Neuroinflammation. 2021 May 11;18(1):112. [Abstract]
- Acta Pharmacol Sin. 2025 Apr 28. [Abstract]
- Cell Rep. 2026 Apr 10;45(4):117246. [Abstract]
- Transl Psychiatry. 2025 May 17;15(1):172. [Abstract]
- Pharmaceutics. 2025 Oct 31;17(11):1415. [Abstract]
- PLoS Biol. 2025 Sep 17;23(9):e3002993. [Abstract]
- CNS Neurosci Ther. 2025 Feb;31(2):e70238. [Abstract]
- CNS Neurosci Ther. 2025 Feb;31(2):e70253. [Abstract]
- CNS Neurosci Ther. 2025 Jan;31(1):e70191. [Abstract]
- Acta Neuropathol Commun. 2024 Nov 22;12(1):179. [Abstract]
- Pharmaceuticals (Basel). 2025 Oct 1;18(10):1481. [Abstract]
- Int Immunopharmacol. 2025 Dec 21:170:116080. [Abstract]
- Int Immunopharmacol. 2025 Mar 27:153:114516. [Abstract]
- Mol Neurobiol. 2025 Jul 17. [Abstract]
- Mol Neurobiol. 2025 Mar;62(3):3934-3955. [Abstract]
- Cell Signal. 2026 Aug:144:112553. [Abstract]
- J Neurochem. 2025 Mar;169(3):e70038. [Abstract]
- Prog Neuropsychopharmacol Biol Psychiatry. 2026 Jun 20:147:111763. [Abstract]
- Mol Brain. 2024 Nov 29;17(1):91. [Abstract]
- Neuroscience. 2025 Dec 5:590:83-92. [Abstract]
- Brain Res. 2022 Oct 15:1793:148052. [Abstract]
- Hum Cell. 2025 Dec 25;39(1):28. [Abstract]
- J Tradit Chin Med. 2022 Jun;42(3):379-388. [Abstract]
- Biochem Biophys Res Commun. 2021 Mar 19:545:195-202. [Abstract]
- Epilepsy Behav. 2025 Jan 18:164:110251. [Abstract]
- Epilepsy Res. 2026 May 14:225:107820. [Abstract]
- Cytotechnology. 2025 Apr;77(2):65. [Abstract]
- Res Sq. 2026 May 4.
- bioRxiv. 2026 Apr 20.
- Authorea. 2024 Dec 27.
- biorxiv. 2024 May 21.
- Research Square Preprint. 2024 Jan 24.
Customer Validation & Images
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Bio/Physico-chemical Assay
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IHC
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RT-PCR
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IHC
Biologische Aktivität
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Animal Model:8 weeks, 200-250 g male adult Wistar rats[1]
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Dosage:5 mg/kg
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Administration:I.p.; hourly at least 3 h until status epilepticus
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Result:Induced seizures in rats.
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.
Kainic acid can be used to create epilepsy models and can be administered systemically, into the hippocampus, or amygdala, and is reproducible in various species. The systemic Kainic acid model closely mimics the manifestations of human temporal lobe epilepsy. When injected at a dose of 5 nM into the neostriatum, substantia nigra, or cerebellum, over half of the Kainic acid disappears from the injection site and brain within 0.5 hours, with radioactivity detected in other brain regions at concentrations lower than 7 pmol/mg[3][4][6].
Administration: 10 μg in 5 μL • i.c.v.
(2) After the operation, skin was sutured, and keep the mice under a warming place until they wake up.
(3) 48 hours after lateral ventricle injection, the mice are anaesthetized using Isoflurane and then sequentially intracardially perfused with saline and PFA (4%, 30 mL). Rapidly remove The mouse brain processed for paraffin embedding or frozen sections.
Histology analysis: Showed Triangulated pyknotic nuclei and cytoplasmic shrinkage in the hippocampal neuron, and induced neuronal loss.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 58002-62-3
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Appearance Solid
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Molecular Weight 231.25
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Formel C10H17NO5
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Color White to off-white
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SMILES
O=C(O)C[C@@H]1[C@@H](C(O)=O)NC[C@@H]1C(C)=C.O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (41)
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Journal Impact Factor
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Most Recent
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Nat Neurosci
GABA-dependent microglial elimination of inhibitory synapses underlies neuronal hyperexcitability in epilepsy. [Abstract]2025 Jul;28(7):1404-1417. PMID: 40425792
Kainic acid hydrate purchased from MedChemExpress. Usage Cited in: Nat Neurosci. 2025 Jul;28(7):1404-1417. [Abstract]
Kainic Acid (KA, i.p., 24 mg/kg, single dose in mouse model of TLE) administration markedly increased microglial calcium signal in both brain regions.
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Nat Neurosci
2023 Apr;26(4):542-554. PMID: 36941428
Kainic acid hydrate purchased from MedChemExpress. Usage Cited in: Nat Neurosci. 2023 Apr;26(4):542-554. [Abstract]
At the chronic stage (21 d after i.p., 24 mg/kg KA injection), both PLIN2/BD493 staining and electron microscopy of mouse hippocampus showed accumulation of LDs in neurons and astrocytes but not in microglia or oligodendrocytes.
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Neuron
Aberrant coupling of glutamate and tyrosine kinase receptors enables neuronal control of brain-tumor growth. [Abstract]2025 Aug 27:S0896-6273(25)00591-4. PMID: 40897174 -
Nat Chem Biol
2024 Dec;20(12):1586-1596. PMID: 38898166 -
J Nanobiotechnology
Improving epilepsy management by targeting P2 × 7 receptor with ROS/electric responsive nanomicelles. [Abstract]2025 May 5;23(1):332. PMID: 40325469
Kainic acid hydrate purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 May 5;23(1):332. [Abstract]
In the TFP@A-treated group, the number and duration of GS were significantly reduced by the second day of Kainic acid (KA, 0.5 mg/mL, 0.5 µL) treatment, with antiepileptic effects lasting until the third day
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Theranostics
Targeted sonogenetic modulation of GABAergic interneurons in the hippocampal CA1 region in status epilepticus. [Abstract]2024 Oct 7;14(16):6373-6391. PMID: 39431014 -
Adv Sci (Weinh)
Microglial GPR35 Ameliorates Epileptogenesis and Neuroinflammation via PDGFA Domain 2 Signaling. [Abstract]2026 Jan 28:e19642. PMID: 41604576 -
Adv Sci (Weinh)
Pigment Epithelium-Derived Factor Deficiency Impairs Hippocampal Glutamate Homeostasis and Cognitive Function by Downregulating Astrocytic GLT-1. [Abstract]2025 Sep 14:e00402. PMID: 40946177 -
Adv Sci (Weinh)
Targeting ROCK2 to Restore Epileptic Synaptic Networks via Mitophagy Activation: Insights from Translational Imaging of SV2A In Vivo. [Abstract]2025 Aug 29:e08161. PMID: 40878444
Kainic acid hydrate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Aug 29:e08161. [Abstract]
ROCK2 inhibition reversed KA (50 μM)-induced suppression of mitophagy, suggesting mitochondrial normalization.
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J Neuroinflammation
The effect of dipeptidyl peptidase IV on disease-associated microglia phenotypic transformation in epilepsy. [Abstract]2021 May 11;18(1):112. PMID: 33975617 -
Acta Pharmacol Sin
Ursolic acid derivative UA312 ameliorates ionizing radiation-induced cardiotoxicity and neurodevelopmental toxicity in zebrafish via targeting chrna3 and grik5. [Abstract]2025 Apr 28. PMID: 40295836 -
Cell Rep
Thalamic glutamatergic neurons regulate seizure onset and generalization in temporal lobe epilepsy. [Abstract]2026 Apr 10;45(4):117246. PMID: 41966823 -
Transl Psychiatry
Stellate ganglion block diminishes consolidation of conditioned fear memory in mice by inhibiting the locus coeruleus to the basolateral amygdala neural circuit. [Abstract]2025 May 17;15(1):172. PMID: 40382311
Kainic acid hydrate purchased from MedChemExpress. Usage Cited in: Transl Psychiatry. 2025 May 17;15(1):172. [Abstract]
KA treatment: Lidocaine (3%) and KA (2 mg/mL) were infused bilaterally into the LC via delivery cannulas connected to the cannula drug delivery system in a 0.2 μL volume per side at a rate of 0.1 μL/10 s 30 min after training. Pharmacological inhibition of the LC reduced conditioned fear memory in mice, whereas activation of the LC reversed the SGB-induced reduction in conditioned fear memory [n = 8, F (3, 28) = 53.26, P < 0.0001; NS + Vehicle vs. NS + Lid, n = 8, P < 0.0001; SGB + Vehicle vs. SGB + KA, n = 8, P < 0.0001].
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Pharmaceutics
8-Hydroxy-2-Anilino-1,4-Naphthoquinone Prevents Against Ferroptotic Neuronal Death and Kainate-Induced Epileptic Seizures. [Abstract]2025 Oct 31;17(11):1415. PMID: 41304754 -
PLoS Biol
Sensitive red fluorescent indicators for real-time visualization of potassium ion dynamics in vivo. [Abstract]2025 Sep 17;23(9):e3002993. PMID: 40961161 -
CNS Neurosci Ther
Astaxanthin Inhibits Ferroptosis of Hippocampal Neurons in Kainic Acid-Induced Epileptic Mice by Activating the Nrf2/GPX4 Signaling Pathway. [Abstract]2025 Feb;31(2):e70238. PMID: 39957487 -
CNS Neurosci Ther
Berberine Alleviates Kainic Acid-Induced Acute Epileptic Seizures in Mice via Reshaping Gut Microbiota-Associated Lipid Metabolism. [Abstract]2025 Feb;31(2):e70253. PMID: 39915895 -
CNS Neurosci Ther
2025 Jan;31(1):e70191. PMID: 39764629 -
Acta Neuropathol Commun
2024 Nov 22;12(1):179. PMID: 39578917 -
Pharmaceuticals (Basel)
2025 Oct 1;18(10):1481. PMID: 41155596 -
Int Immunopharmacol
CGRP alleviates epilepsy via JAK1-STAT1-P2RX7 signaling: a novel neuroprotective axis targeting neuronal damage. [Abstract]2025 Dec 21:170:116080. PMID: 41429063 -
Int Immunopharmacol
Melatonin alleviates retinal injury induced by vigabatrin and partially enhances its antiepileptic effects. [Abstract]2025 Mar 27:153:114516. PMID: 40154179 -
Mol Neurobiol
REST/NRSF Regulation of Epilepsy and Cognitive Impairment: Mechanisms and EEG Correlations. [Abstract]2025 Jul 17. PMID: 40676365 -
Mol Neurobiol
2025 Mar;62(3):3934-3955. PMID: 39354232 -
Cell Signal
Clec7a promotes hippocampal microglial activation in rats with status epilepticus via inducing the TLR4/MyD88/NF-κB signaling pathway. [Abstract]2026 Aug:144:112553. PMID: 42025892 -
J Neurochem
Cannabidiol Protects Against Neurotoxic Reactive Astrocytes-Induced Neuronal Death in Mouse Model of Epilepsy. [Abstract]2025 Mar;169(3):e70038. PMID: 40099400 -
Prog Neuropsychopharmacol Biol Psychiatry
Microglial HMGB2 mediates neuroinflammation and brain damage in Cx3cr1-creERT2 epileptic mice through astrocyte-derived CCL2. [Abstract]2026 Jun 20:147:111763. PMID: 42218973 -
Mol Brain
2024 Nov 29;17(1):91. PMID: 39614352 -
Neuroscience
Suppression of AKAP150 palmitoylation alleviates seizures in kainic acid-induced epilepsy mice. [Abstract]2025 Dec 5:590:83-92. PMID: 41187801 -
Brain Res
Lipopolysaccharide (LPS) increases susceptibility to epilepsy via interleukin-1 type 1 receptor signaling. [Abstract]2022 Oct 15:1793:148052. PMID: 35970265 -
Hum Cell
Neuroprotective activity of thiolutin in epileptic mice: the inhibition of NLRP3 inflammasome. [Abstract]2025 Dec 25;39(1):28. PMID: 41447420 -
J Tradit Chin Med
Electroacupuncture preconditioning alleviates myocardial ischemia-reperfusion injury through the hypothalamic paraventricular nucleus- interposed nucleus nerve pathway. [Abstract]2022 Jun;42(3):379-388. PMID: 35610007 -
Biochem Biophys Res Commun
miR-128 regulates epilepsy sensitivity in mice by suppressing SNAP-25 and SYT1 expression in the hippocampus. [Abstract]2021 Mar 19:545:195-202. PMID: 33571908 -
Epilepsy Behav
Butylphthalide may inhibit blood-brain barrier disruption through complement-related pathways to alleviate cognitive impairment in epileptic mice. [Abstract]2025 Jan 18:164:110251. PMID: 39827680 -
Epilepsy Res
Vitamin D3 prevents epileptic seizures by modulating the ras signalling pathway via Gnb1 and Casr in acute epilepsy mouse models. [Abstract]2026 May 14:225:107820. PMID: 42150281 -
Cytotechnology
Identification of plasma exosomal microRNAs and bioinformatics analysis of the microRNA-messenger RNA regulatory pathways in mice with status epilepticus. [Abstract]2025 Apr;77(2):65. PMID: 39991702 -
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Verweise
[1]. Cincioğlu-Palabiyik M, et al. Chronic levetiracetam decreases hippocampal and testicular aromatase expression in normal but not kainic acid-induced experimental model of acute seizures in rats. Neuroreport. 2017 Sep 27;28(14):903-909. [Content Brief]
[2]. Wang Q, et al. Kainic acid-mediated excitotoxicity as a model for neurodegeneration. Mol Neurobiol. 2005;31(1-3):3-16. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Kainic acid hydrate Related Classifications
HY-N2309A Related Classifications
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