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Art. -Nr.: HY-182793

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MLL1-IN-1

MLL1-IN-1 is an orally active MLL1 inhibitor with an IC₅₀ of 0.043 μM. MLL1-IN-1 induces Menin protein degradation and inhibits the proliferation of leukemia cells. MLL1-IN-1 can induce tumor regression in leukemia-bearing mice. MLL1-IN-1 is useful for research into MLL1-associated leukemia.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 3058433-50-1
Formel: C₃₄H₄₄FN₅O₃
Molecular Weight:589.74

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

MLL1-IN-1 Chemical Structure

CAS. Nr.: 3058433-50-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
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Bioz

Biologische Aktivität

Beschreibung

Alle Histone Methyltransferase Isoform-spezifische Produkte anzeigen :

In Vitro

MLL1-IN-1 (7 days) inhibits the viability of MOLM-13, MV-4-11, and OCI-AML3 cells, with IC₅₀ values of 0.04, 0.035, and 0.047 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MLL1-IN-1 (30-200 mg/kg, p.o., twice daily for 14 days) induces tumor regression in an MV-4-11 subcutaneous xenograft mouse model^[1].
MLL1-IN-1 (30-200 mg/kg, p.o., once daily for 21/90 days) induces tumor regression in a MOLM-13 subcutaneous xenograft mouse model^[1].
MLL1-IN-1 (150 mg/kg, p.o., once daily for 21 days) prolongs survival in an MLL-r AML patient-derived xenograft (PDX) mouse model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Female CB17 SCID mice with MV-4-11 subcutaneous xenograft^[1]
Dosage:

30, 100, 200 mg/kg
Administration:

p.o., twice daily for 14 days
Result:

Reduced tumors by 88%, with a 100% recurrence rate following drug discontinuation at a dose of 30 mg/kg. Reduced tumors by 97%/99%, with no recurrence observed 6 weeks after drug discontinuation at doses of 100/200 mg/kg.

Chemical Information

CAS. Nr. 3058433-50-1
Molecular Weight 589.74
Formel C₃₄H₄₄FN₅O₃
SMILES

FC1=CC=[C@]([N@]2C(C=NC=C3)=C3C(C(C4CCN(C([C@@H]5CCC(C)(C)N5)=O)CC4)=O)=C2C)C(C(N(C(C)C)C(C)C)=O)=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Dedong Wu, et al. Solid-state forms of ((s)-2-(3-(1-(5,5-dimethylpyrrolidine-2-carbonyl)piperidine-4-carbonyl)-2-methyl-1h-pyrrolo[2,3-c]-pyridin-1-yl)-5-fluoro-n,n-diisopropylbenzamide salts. WO2026062248A1. 2026-03-26.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
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MLL1-IN-1

Alle Histone Methyltransferase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

MLL1-IN-1 Related Classifications

HY-182793 Related Classifications