PDE5/CA-IN-1
PDE5/CA-IN-1 is a dual PDE5 and carbonic anhydrase (CA) inhibitor, with IC50 values of 0.41, 38.4, and 9.1 nM against PDE5, hCA II, and hCA VA, respectively. PDE5/CA-IN-1 inhibits multiple hCA subtypes associated with Alzheimer's disease. As a cytoprotective agent and oxidative stress alleviator, PDE5/CA-IN-1 reduces oxidative stress, and prevents recognition memory and working memory impairments. PDE5/CA-IN-1 is available for the research of Alzheimer's disease.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C24H28N6O6S2
- Molecular Weight:560.65
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
PDE5/CA-IN-1 (Compound 8a) (12.5-100 μM; 24 h) confers protection against Aβ1-42 oligomer-induced cytotoxicity and oxidative stress in differentiated SH-SY5Y cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CD1 (male, 8-9 weeks old, Alzheimer's disease model via unilateral intracerebroventricular injection of Aβ1-42 peptide)[1]
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Dosage:4 mg/kg
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Administration:i.p.; once daily; 21 consecutive days
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Result:Showed significantly higher discrimination index in novel object recognition test 14 days post-Aβ injection.
Exhibited significantly higher percentage of spontaneous alternations in Y-maze test.
Reduced carbonic anhydrase activity in cortical brain region; no significant change observed in hippocampal region.
Chemical Information
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Molecular Weight 560.65
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Formel C24H28N6O6S2
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SMILES
CCOC1=C(C2=NC(C(CCC)=NN3C)=C3C(N2)=O)C=C(S(NCC4=CC=C(S(=O)(N)=O)C=C4)(=O)=O)C=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
PDE5/CA-IN-1 Related Classifications
HY-181684 Related Classifications
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