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Art. -Nr.: HY-123004

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S 4404

S 4404 is a prolyl-4-hydroxylase inhibitor. S 4404 functions as a non-substrate of hepatobiliary transport systems. S 4404 undergoes metabolic breakdown into fluorescent and red-colored metabolites. S 4404 can be used for the research of liver fibrosis.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 143199-54-6
Formel: C₂₈H₃₃N₇O₉
Molecular Weight:611.60

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

S 4404 Chemical Structure

CAS. Nr.: 143199-54-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle HIF/HIF Prolyl-Hydroxylase Isoform-spezifische Produkte anzeigen :

In Vivo

S 4404 (1 mM; i.v.; single bolus) is not transported in intact form from portal blood into bile, with less than 4% of the intact compound appearing in bile within 40 minutes of administration^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar (male, 400-500 g)^[1]
Dosage:

1 mM
Administration:

i.v.; single bolus
Result:

Secreted less than 4% in intact form into bile within 40 minutes.
Secreted approximately 28% as metabolite M₂ into bile within 40 minutes.

Chemical Information

CAS. Nr. 143199-54-6
Molecular Weight 611.60
Formel C₂₈H₃₃N₇O₉
SMILES

[O-][N+](C(C1=NON=C21)=CC=C2NCCC(N[C@@H](CC3=CC=CC=C3)C(N4[C@H](C(NCC(OC(C)(C)C)=O)=O)CCO4)=O)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Kramer W, et al. Liver-specific drug targeting by coupling to bile acids. J Biol Chem. 1992 Sep 15;267(26):18598-604.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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