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Art. -Nr.: HY-180212

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SYK-1106

SYK-1106 is a potent delta-opioid receptor (DOR) agonist with an EC₅₀ of 89 pM and a K_i of 848 pM. SYK-1106 is selective for μ and κ opioid receptors, with K_i values of 9.54 nM and 2.45 nM, respectively. SYK-1106 induces dose-dependent antidepressant-like effects. SYK-1106 can be used for the research of depression.

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CAS. Nr.: 2643940-93-4
Formel: C₂₈H₃₇N₃O₂
Molecular Weight:447.61

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

SYK-1106 Chemical Structure

CAS. Nr.: 2643940-93-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

δ Opioid Receptor/DOR

0.848 nM (Ki)

μ Opioid Receptor/MOR

9.54 nM (Ki)

κ Opioid Receptor/KOR

2.45 nM (Ki)

Alle Opioid Receptor Isoform-spezifische Produkte anzeigen :

In Vivo

SYK-1106 (0.03-0.3 mg/kg; s.c.; single dose) produces dose-dependent DOR-mediated antidepressant-like effects in the mouse forced-swim test, with significant activity starting at 0.1 mg/kg and maximal effects at 0.3 mg/kg, without altering locomotor activity or inducing convulsions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

ICR mice (male, 5 weeks old, acclimatized for ~7 days before experiments)^[1]
Dosage:

0.03 mg/kg; 0.1 mg/kg; 0.3 mg/kg
Administration:

s.c.; single dose (30 minutes before test sessions)
Result:

Did not significantly alter immobility, swimming, or climbing counts at 0.03 mg/kg compared to vehicle.
Significantly reduced immobility counts and increased swimming counts at 0.1 mg/kg.
Produced the largest significant reduction in immobility counts, along with significant increases in swimming and climbing counts at 0.3 mg/kg.
Had antidepressant-like effects completely reversed by co-administration with NTI at 0.3 mg/kg.
Did not significantly alter locomotor activity at 0.3 mg/kg compared to vehicle.
Caused no convulsive effects at any tested dose.

Chemical Information

CAS. Nr. 2643940-93-4
Molecular Weight 447.61
Formel C₂₈H₃₇N₃O₂
SMILES

O[C@]12[C@H]3CC(C=CC(O)=C4)=C4[C@@]1(CCN3CC5CC5)CC6=C(C2)C(C)=NN6C7CCCCC7
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Fujii H, et al. Design and Synthesis of Pyrazolomorphinan Derivatives as Novel Delta Opioid Receptor Agonists. J Med Chem. 2025;68(24):25794-25808. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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SYK-1106

Alle Opioid Receptor Isoform-spezifische Produkte anzeigen