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Cat. No.: HY-N19701

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Calphostin I

Calphostin I is a selective protein kinase C (PKC) inhibitor with an IC₅₀ of 0.14 μM in rats. Calphostin I interacts with the regulatory domain of PKC, and the aromatic groups at its C-14 and C-17 positions contribute to enhanced potency and selectivity, with no inhibition of cyclic adenosine monophosphate-dependent protein kinase (PKA) at high concentrations. Calphostin I can be used in research related to cervical cancer and breast cancer.

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CAS No.: 124857-59-6
Formule: C₄₄H₃₈O₁₅
Masse moléculaire:806.76

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Please store the product under the recommended conditions in the Certificate of Analysis.

Calphostin I Chemical Structure

CAS No.: 124857-59-6

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
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Activité biologique

Description

IC₅₀ & Target^[1]

PKC

0.14 μM (IC₅₀)

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In Vitro

Calphostin I potently and selectively inhibits partially purified rat brain PKC with an IC₅₀ of 0.14 μM, and does not inhibit partially purified bovine heart PKA at concentrations up to 50 μM^[1].
Calphostin I (1 h) inhibits the growth of human cervical cancer HeLa S₃ cells with an IC₅₀ of 0.24 μM and human breast cancer MCF-7 cells with an IC₅₀ of 0.16 μM in vitro^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 124857-59-6
Masse moléculaire 806.76
Formule C₄₄H₃₈O₁₅
SMILES

O=C(OC(CC1=C(C(C2=C(C=C(C(C3=C4C5=C(O)C=C3OC)=C2C1=C4C(CC(C)OC(C6=CC=C(C=C6)O)=O)=C(OC)C5=O)OC)O)=O)OC)C)OC7=CC=C(C=C7)O
Structure Classification
- Phenols
- Polyphenols
Initial Source
- Microorganisms
Cladosporium cladosporioides
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Kobayashi E, et al. Calphostins (UCN-1028), novel and specific inhibitors of protein kinase C. I. Fermentation, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo). 1989 Oct;42(10):1470-4. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
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- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
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Calphostin I

Voir tous les produits spécifiques à Isoform PKC

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Calphostin I Related Classifications

HY-N19701 Related Classifications