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Cat. No.: HY-187495A

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DOPE-PEG2000-MG1

DOPE-PEG2000-MG1 is an amphiphilic lipid-PEG-peptide conjugate comprising DOPE (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine), PEG2000, and the MG1 peptide. MG1 peptide functions as a tumor-targeting ligand that specifically recognizes proteins overexpressed on tumor cell surfaces. DOPE-PEG2000-MG1 is used to modify liposomes and lipid nanoparticles for active tumor-targeted drug delivery.

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Please store the product under the recommended conditions in the Certificate of Analysis.

DOPE-PEG2000-MG1 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Activité biologique

Description

In Vitro

DOPE-PEG2000-MG1: surface decoration of liposomes and nanocarriers for tumor-targeted drug delivery, enabling selective accumulation in tumor tissues and enhanced cellular uptake by cancer cells.
Structural composition:
(1) DOPE; a phospholipid with two oleoyl chains that serves as a stable hydrophobic anchor in lipid bilayers and promotes pH-dependent membrane fusion for endosomal escape;
(2) PEG2000; a hydrophilic polymer chain that forms a protective hydration layer reducing immune recognition and extending blood circulation half-life;
(3) MG1 peptide; a targeting ligand that specifically binds to receptors or proteins overexpressed on tumor cell surfaces, acting as a navigation module to direct nanocarriers to tumor tissues for improved therapeutic efficacy and reduced systemic toxicity.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

SMILES

[DOPE-PEG2000-MG1]
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.