Sox9 - SRY (sex determining region Y)-box 9 Gene

Also Known as mSox9; mKIAA4243; 2010306G03Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20682

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; beta-catenin binding activity; and nucleic acid binding activity. Involved in several processes, including intracellular signal transduction; positive regulation of morphogenesis of an epithelium; and regulation of signal transduction. Acts upstream of or within several processes, including animal organ development; negative regulation of cell differentiation; and regulation of epithelial cell proliferation. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study campomelic dysplasia. Human ortholog(s) of this gene implicated in 46,XX sex reversal 2; 46,XY sex reversal 10; and campomelic dysplasia. Orthologous to human SOX9 (SRY-box transcription factor 9). [provided by Alliance of Genome Resources, Apr 2022]

Sox9 Products (1)

mRNA Protein Name
NM_011448.4 NP_035578.3 transcription factor SOX-9

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables DNA binding IDA
IDA: Inferred from direct assay
18403418 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
10805756 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
9755172 MGI
enables DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
17084361 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
17525254 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15590666 MGI
enables beta-catenin binding IDA
IDA: Inferred from direct assay
15132997 MGI
enables beta-catenin binding IPI
IPI: Inferred from physical interaction
19725955 MGI
enables cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
10805756 MGI
enables pre-mRNA intronic binding IDA
IDA: Inferred from direct assay
24191021 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12381733 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15800003 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
9119111 MGI
Biological Process GO Annotation Evidence Références Source
involved in ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
21512138 MGI
acts upstream of or within Harderian gland development IMP
IMP: Inferred from mutant phenotype
24924191 MGI
acts upstream of or within Notch signaling pathway IDA
IDA: Inferred from direct assay
25446530 MGI
acts upstream of or within Sertoli cell development IGI
IGI: Inferred from genetic interaction
19124014 MGI
acts upstream of or within Sertoli cell differentiation IMP
IMP: Inferred from mutant phenotype
15056615 MGI
acts upstream of or within anterior head development IMP
IMP: Inferred from mutant phenotype
26234751 MGI
acts upstream of apoptotic process IMP
IMP: Inferred from mutant phenotype
16085486 MGI
acts upstream of or within astrocyte fate commitment IGI
IGI: Inferred from genetic interaction
19490914 MGI
acts upstream of bone mineralization IMP
IMP: Inferred from mutant phenotype
11371614 MGI
involved in branching involved in ureteric bud morphogenesis IEP
IEP: Inferred from expression pattern
8787755 MGI
acts upstream of or within bronchus cartilage development IMP
IMP: Inferred from mutant phenotype
24218621 MGI
acts upstream of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
19047045 MGI
acts upstream of or within cartilage condensation IMP
IMP: Inferred from mutant phenotype
10319868 MGI
acts upstream of cartilage development IDA
IDA: Inferred from direct assay
19047045 MGI
involved in cartilage development IDA
IDA: Inferred from direct assay
15529345 MGI
acts upstream of or within cartilage development IMP
IMP: Inferred from mutant phenotype
11371614 MGI
involved in cartilage development IMP
IMP: Inferred from mutant phenotype
28263186 MGI
acts upstream of or within cell fate commitment IGI
IGI: Inferred from genetic interaction
15893981 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
17267606 MGI
acts upstream of cell proliferation involved in heart morphogenesis IMP
IMP: Inferred from mutant phenotype
17350610 MGI
acts upstream of or within cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
24191021 MGI
involved in cellular response to epidermal growth factor stimulus IDA
IDA: Inferred from direct assay
21512138 MGI
involved in cellular response to heparin IDA
IDA: Inferred from direct assay
21512138 MGI
involved in cellular response to mechanical stimulus IDA
IDA: Inferred from direct assay
21512138 MGI
acts upstream of or within cellular response to retinoic acid IDA
IDA: Inferred from direct assay
19389355 MGI
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: Inferred from expression pattern
17525254 MGI
involved in central nervous system development IEP
IEP: Inferred from expression pattern
9119111 MGI
acts upstream of or within chondrocyte development IMP
IMP: Inferred from mutant phenotype
18415932 MGI
involved in chondrocyte differentiation IDA
IDA: Inferred from direct assay
32103177 MGI
involved in chondrocyte differentiation IEP
IEP: Inferred from expression pattern
9119111 MGI
acts upstream of chondrocyte differentiation IMP
IMP: Inferred from mutant phenotype
11371614 MGI
acts upstream of or within chondrocyte differentiation IMP
IMP: Inferred from mutant phenotype
12414734 MGI
involved in chondrocyte differentiation IMP
IMP: Inferred from mutant phenotype
15132997 MGI
involved in chondrocyte hypertrophy IMP
IMP: Inferred from mutant phenotype
21367821 MGI
acts upstream of or within cochlea morphogenesis IMP
IMP: Inferred from mutant phenotype
20346939 MGI
acts upstream of or within cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
24191021 MGI
acts upstream of or within endocardial cushion morphogenesis IMP
IMP: Inferred from mutant phenotype
11951052 MGI
acts upstream of or within endochondral bone morphogenesis IMP
IMP: Inferred from mutant phenotype
11371614 MGI
acts upstream of or within endocrine pancreas development IMP
IMP: Inferred from mutant phenotype
18723011 MGI
involved in epidermal growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
21512138 MGI
acts upstream of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
17698607 MGI
acts upstream of or within epithelial cell proliferation involved in prostatic bud elongation IMP
IMP: Inferred from mutant phenotype
18325490 MGI
acts upstream of or within epithelial to mesenchymal transition IMP
IMP: Inferred from mutant phenotype
15096597 MGI
acts upstream of or within epithelial tube branching involved in lung morphogenesis IGI
IGI: Inferred from genetic interaction
24058167 MGI
acts upstream of or within epithelial tube branching involved in lung morphogenesis IMP
IMP: Inferred from mutant phenotype
24058167 MGI
acts upstream of extracellular matrix assembly IMP
IMP: Inferred from mutant phenotype
20881014 MGI
acts upstream of or within extracellular matrix organization IMP
IMP: Inferred from mutant phenotype
17350610 MGI
involved in gene expression IMP
IMP: Inferred from mutant phenotype
29659575 MGI
acts upstream of glandular epithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
17681175 MGI
acts upstream of or within glial cell fate specification IMP
IMP: Inferred from mutant phenotype
12842915 MGI
involved in growth plate cartilage chondrocyte growth IMP
IMP: Inferred from mutant phenotype
22421045 MGI
acts upstream of or within hair follicle development IMP
IMP: Inferred from mutant phenotype
16085486 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
15096597 MGI
involved in heart valve development IMP
IMP: Inferred from mutant phenotype
20056916 MGI
acts upstream of or within heart valve formation IMP
IMP: Inferred from mutant phenotype
17350610 MGI
acts upstream of or within heart valve morphogenesis IMP
IMP: Inferred from mutant phenotype
17350610 MGI
acts upstream of or within homeostasis of number of cells within a tissue IMP
IMP: Inferred from mutant phenotype
24218621 MGI
acts upstream of intestinal epithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
17681175 MGI
acts upstream of or within intestinal epithelial structure maintenance IMP
IMP: Inferred from mutant phenotype
17681175 MGI
acts upstream of or within intrahepatic bile duct development IMP
IMP: Inferred from mutant phenotype
19403103 MGI
acts upstream of or within lacrimal gland development IMP
IMP: Inferred from mutant phenotype
24924191 MGI
involved in limb bud formation IEP
IEP: Inferred from expression pattern
20940257 MGI
acts upstream of or within lung epithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
24191021 MGI
acts upstream of or within lung smooth muscle development IMP
IMP: Inferred from mutant phenotype
24218621 MGI
acts upstream of or within male germ-line sex determination IMP
IMP: Inferred from mutant phenotype
11431689 MGI
involved in male gonad development IEP
IEP: Inferred from expression pattern
8787755 MGI
acts upstream of or within male gonad development IGI
IGI: Inferred from genetic interaction
15056615 MGI
acts upstream of or within male gonad development IMP
IMP: Inferred from mutant phenotype
11431689 MGI
acts upstream of or within male sex determination IGI
IGI: Inferred from genetic interaction
16700629 MGI
involved in mammary gland development IEP
IEP: Inferred from expression pattern
12420222 MGI
acts upstream of mesenchymal cell apoptotic process IMP
IMP: Inferred from mutant phenotype
24058167 MGI
acts upstream of mesenchymal cell proliferation IMP
IMP: Inferred from mutant phenotype
17350610 MGI
acts upstream of or within metanephric nephron tubule formation IGI
IGI: Inferred from genetic interaction
21212101 MGI
involved in metanephric tubule development IEP
IEP: Inferred from expression pattern
8787755 MGI
acts upstream of or within morphogenesis of a branching epithelium IGI
IGI: Inferred from genetic interaction
21212101 MGI
acts upstream of or within morphogenesis of a branching epithelium IMP
IMP: Inferred from mutant phenotype
24924191 MGI
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12782625 MGI
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
21212101 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16085486 MGI
involved in negative regulation of beta-catenin-TCF complex assembly IMP
IMP: Inferred from mutant phenotype
15132997 MGI
involved in negative regulation of biomineral tissue development IMP
IMP: Inferred from mutant phenotype
20056916 MGI
acts upstream of or within negative regulation of bone mineralization IMP
IMP: Inferred from mutant phenotype
11371614 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
17698607 MGI
involved in negative regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
17875931 MGI
involved in negative regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
15132997 MGI
acts upstream of or within negative regulation of chondrocyte differentiation IMP
IMP: Inferred from mutant phenotype
11371614 MGI
acts upstream of or within negative regulation of epithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
24058167 MGI
acts upstream of or within negative regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
17681175 MGI
involved in negative regulation of fatty acid oxidation IDA
IDA: Inferred from direct assay
32103177 MGI
acts upstream of or within negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
24218621 MGI
involved in negative regulation of immune system process IMP
IMP: Inferred from mutant phenotype
20056916 MGI
acts upstream of or within negative regulation of mesenchymal cell apoptotic process IMP
IMP: Inferred from mutant phenotype
24058167 MGI
acts upstream of or within negative regulation of myoblast differentiation IDA
IDA: Inferred from direct assay
12782625 MGI
involved in negative regulation of ossification IMP
IMP: Inferred from mutant phenotype
20056916 MGI
involved in negative regulation of osteoblast differentiation IDA
IDA: Inferred from direct assay
31121357 MGI
involved in negative regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
22421045 MGI
acts upstream of or within negative regulation of photoreceptor cell differentiation IGI
IGI: Inferred from genetic interaction
19490914 MGI
acts upstream of or within neural crest cell development IMP
IMP: Inferred from mutant phenotype
15691760 MGI
acts upstream of or within neuron fate specification IMP
IMP: Inferred from mutant phenotype
12842915 MGI
involved in notochord development IEP
IEP: Inferred from expression pattern
9119111 MGI
acts upstream of or within oligodendrocyte differentiation IMP
IMP: Inferred from mutant phenotype
17084361 MGI
involved in ossification IEP
IEP: Inferred from expression pattern
9119111 MGI
involved in otic vesicle development IEP
IEP: Inferred from expression pattern
9119111 MGI
acts upstream of or within otic vesicle formation IMP
IMP: Inferred from mutant phenotype
18377888 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15778499 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
9119111 MGI
acts upstream of or within positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
17084361 MGI
involved in positive regulation of branching involved in ureteric bud morphogenesis IMP
IMP: Inferred from mutant phenotype
21212101 MGI
acts upstream of or within positive regulation of cartilage development IDA
IDA: Inferred from direct assay
19047045 MGI
acts upstream of or within positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
17267606 MGI
acts upstream of or within positive regulation of cell proliferation involved in heart morphogenesis IMP
IMP: Inferred from mutant phenotype
17350610 MGI
involved in positive regulation of chondrocyte differentiation IDA
IDA: Inferred from direct assay
20940257 MGI
involved in positive regulation of chondrocyte differentiation IMP
IMP: Inferred from mutant phenotype
21367821 MGI
acts upstream of or within positive regulation of epithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
17681175 MGI
acts upstream of or within positive regulation of epithelial cell migration IMP
IMP: Inferred from mutant phenotype
24191021 MGI
acts upstream of or within positive regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
20346939 MGI
involved in positive regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
20103652 MGI
acts upstream of or within positive regulation of extracellular matrix assembly IMP
IMP: Inferred from mutant phenotype
20881014 MGI
acts upstream of or within positive regulation of gene expression IGI
IGI: Inferred from genetic interaction
19124014 MGI
involved in positive regulation of kidney development IGI
IGI: Inferred from genetic interaction
21212101 MGI
acts upstream of or within positive regulation of mesenchymal cell proliferation IMP
IMP: Inferred from mutant phenotype
17350610 MGI
acts upstream of or within positive regulation of protein catabolic process IDA
IDA: Inferred from direct assay
19047045 MGI
acts upstream of or within positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
19047045 MGI
acts upstream of or within positive regulation of stem cell proliferation IMP
IMP: Inferred from mutant phenotype
17350610 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9171829 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17525254 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
9755172 MGI
involved in positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
22110751 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
21757499 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
20940257 MGI
involved in prostate gland development IEP
IEP: Inferred from expression pattern
20103652 MGI
acts upstream of or within prostate gland morphogenesis IMP
IMP: Inferred from mutant phenotype
18325490 MGI
acts upstream of or within protein localization to nucleus IDA
IDA: Inferred from direct assay
21427722 MGI
acts upstream of protein phosphorylation IDA
IDA: Inferred from direct assay
19047045 MGI
acts upstream of or within regulation of branching involved in lung morphogenesis IMP
IMP: Inferred from mutant phenotype
24191021 MGI
acts upstream of or within regulation of cell adhesion IMP
IMP: Inferred from mutant phenotype
18377888 MGI
acts upstream of or within regulation of cell differentiation IMP
IMP: Inferred from mutant phenotype
17698607 MGI
acts upstream of or within regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
16085486 MGI
acts upstream of or within regulation of cell proliferation involved in tissue homeostasis IMP
IMP: Inferred from mutant phenotype
17698607 MGI
acts upstream of or within regulation of epithelial cell proliferation involved in lung morphogenesis IMP
IMP: Inferred from mutant phenotype
24191021 MGI
acts upstream of or within regulation of gene expression IDA
IDA: Inferred from direct assay
27325675 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19796622 MGI
involved in renal vesicle induction IMP
IMP: Inferred from mutant phenotype
21212101 MGI
involved in response to fatty acid IDA
IDA: Inferred from direct assay
32103177 MGI
acts upstream of or within retina development in camera-type eye IGI
IGI: Inferred from genetic interaction
19490914 MGI
acts upstream of retinal rod cell differentiation IGI
IGI: Inferred from genetic interaction
19490914 MGI
acts upstream of or within retinal rod cell differentiation IGI
IGI: Inferred from genetic interaction
19490914 MGI
involved in signal transduction IMP
IMP: Inferred from mutant phenotype
21212101 MGI
acts upstream of or within somatic stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
20871603 MGI
acts upstream of or within spermatogenesis IGI
IGI: Inferred from genetic interaction
19124014 MGI
acts upstream of stem cell proliferation IMP
IMP: Inferred from mutant phenotype
17350610 MGI
involved in tissue homeostasis IMP
IMP: Inferred from mutant phenotype
20056916 MGI
acts upstream of or within trachea cartilage development IMP
IMP: Inferred from mutant phenotype
24218621 MGI
acts upstream of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17644814 MGI
acts upstream of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
21427722 MGI
acts upstream of type I pneumocyte differentiation IMP
IMP: Inferred from mutant phenotype
24058167 MGI
acts upstream of or within ureter development IGI
IGI: Inferred from genetic interaction
20881014 MGI
acts upstream of or within ureter morphogenesis IGI
IGI: Inferred from genetic interaction
21212101 MGI
acts upstream of or within ureter smooth muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
20881014 MGI
involved in ureter urothelium development IEP
IEP: Inferred from expression pattern
21512138 MGI
Cellular Component GO Annotation Evidence Références Source
located in nucleus IDA
IDA: Inferred from direct assay
10805756 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
22344693 MGI
part of transcription regulator complex IPI
IPI: Inferred from physical interaction
21346191 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor SOX-9

  • SRY-box containing gene 9

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-19820A NSC45586 sodium 98.0% Unkown
HY-RS13599 SOX9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N12540 Monogalactosyldiacylglycerol 99.9% Unkown
HY-RS17376 Sox9 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23830 Sox9 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sox9 NCBI NCBI:6662