2. Immunology/Inflammation
  3. Complement System
  4. CP-447697

CP-447697 is a lipophilic C5a receptor antagonist with an IC50 value of 31 nM. CP-447697 can be used for the research of inflammation.

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CP-447697

CP-447697 構造式

CAS 番号 : 1092847-21-6

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 73 在庫あり
Solution
10 mM * 1 mL in DMSO USD 73 在庫あり
Solid
5 mg $60 在庫あり
10 mg $100 在庫あり
25 mg $200 在庫あり
50 mg $315 在庫あり
100 mg $465 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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Based on 0 publication(s) in Google Scholar

CP-447697 関連抗体

Top Publications Citing Use of Products

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

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製品説明

CP-447697 is a lipophilic C5a receptor antagonist with an IC50 value of 31 nM. CP-447697 can be used for the research of inflammation[1].

IC50 & Target

IC50: 31 nM (C5a receptor)[1]
Cellular Effect
Cell Line Type Value Description References
Neutrophil IC50
250 nM
Compound: 2, CP-447697
Inhibition of C5a-induced elastase release in human neutrophils measured by cleavage of chromogenic MeO-Suc-Ala-Ala-ProlVal-pNA
Inhibition of C5a-induced elastase release in human neutrophils measured by cleavage of chromogenic MeO-Suc-Ala-Ala-ProlVal-pNA
[PMID: 18809326]
U-937 IC50
31 nM
Compound: 2, CP-447697
Displacement of [125I]r-hC5a from C5a receptor in cAMP differentiated human U937 cells
Displacement of [125I]r-hC5a from C5a receptor in cAMP differentiated human U937 cells
[PMID: 18809326]
分子量

554.05

分子式

C29H26ClF2N3O2S
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

ClC(C=C1)=CC=C1CCN(C(C2=CSC3=C2C=CC=C3)=O)C4CCN(C(NC5=CC=C(F)C=C5F)=O)CC4
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
体外: 

DMSO : 125 mg/mL (225.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8049 mL 9.0245 mL 18.0489 mL
5 mM 0.3610 mL 1.8049 mL 3.6098 mL
10 mM 0.1805 mL 0.9024 mL 1.8049 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8049 mL 9.0245 mL 18.0489 mL 45.1223 mL
5 mM 0.3610 mL 1.8049 mL 3.6098 mL 9.0245 mL
10 mM 0.1805 mL 0.9024 mL 1.8049 mL 4.5122 mL
15 mM 0.1203 mL 0.6016 mL 1.2033 mL 3.0082 mL
20 mM 0.0902 mL 0.4512 mL 0.9024 mL 2.2561 mL
25 mM 0.0722 mL 0.3610 mL 0.7220 mL 1.8049 mL
30 mM 0.0602 mL 0.3008 mL 0.6016 mL 1.5041 mL
40 mM 0.0451 mL 0.2256 mL 0.4512 mL 1.1281 mL
50 mM 0.0361 mL 0.1805 mL 0.3610 mL 0.9024 mL
60 mM 0.0301 mL 0.1504 mL 0.3008 mL 0.7520 mL
80 mM 0.0226 mL 0.1128 mL 0.2256 mL 0.5640 mL
100 mM 0.0180 mL 0.0902 mL 0.1805 mL 0.4512 mL
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CP-447697 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CP-4476971092847-21-6CP447697CP 447697Complement Systemlibrary screeninflammationlipophilicrapidly metabolizeInhibitorinhibitorinhibit

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製品名:
CP-447697
製品番号:
HY-112199
数量:
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