Cyclamic acid calcium
Cyclamic acid (Cyclamate) calcium is a commonly used and orally active sweetener. Cyclamic acid calcium is toxic to osteoblasts and can inhibit cell proliferation, induce apoptosis and reduce cell mineralization. Cyclamic acid calcium causes focal necrosis of bladder organs in rats in vitro, which can promote bladder cancer, but some studies have shown that low doses of Cyclamic acid calcium have no carcinogenic effect. In addition, Cyclamic acid calcium has no effect on insulin and glucagon secretion induced by arginine.
For research use only. We do not sell to patients.
- CAS No.: 139-06-0
- Formula: C6H13NO3S·1/2Ca
- Molecular Weight:219.02
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
- Annexin V plus membrane-impermeant dye apoptosis staining
- BrdU Incorporation Assay
- Somatic Cell Culture
- CFSE Dye Dilution Proliferation Assay
- Dye-dilution cell tracking and proliferation staining
- CCK-8/WST-8 Cell Proliferation Assay
- Protocol for Cell Cycle
- Cell Counting-Based Growth Curve Assay
- Colony Formation (Clonogenic) Assay
- Cell Viability Determination by MTT Colorimetric Assay
- EdU Incorporation Assay (Click Chemistry-Based DNA Synthesis Measurement)
- Ki-67 Immunostaining Proliferation Assay
- Detection of Apoptosis
- TUNEL staining for apoptotic DNA fragmentation
- PCNA Immunodetection Proliferation Assay
- Protocol for Cell Counting and Cell Density Analysis
- Mesenchymal stromal/stem cell osteogenic differentiation
- Research Protocol for Endocrine Diseases
- Apoptosis Solutions
- MTT Cell Proliferation Assay
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 139-06-0
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Molecular Weight 219.02
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Formula C6H13NO3S·1/2Ca
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SMILES
O=S(NC1CCCCC1)([O-])=O.[Ca+2].[1/2]
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Synonyms
Cyclohexylsulfamic acid calcium; Cyclamate calcium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cyclamic acid calcium Related Classifications
HY-W719824 Related Classifications
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