Cyclamic acid (Synonyms: Cyclohexylsulfamic acid; Cyclamate)

Cat. No.: HY-B0541 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Cyclamic acid (Cyclohexylsulfamic acid) is one of the most widely used artificial sweetenersin food and pharmaceuticals.

For research use only. We do not sell to patients.

Cyclamic acid Chemical Structure

CAS No. : 100-88-9

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 55	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 55	In-stock	Estimated Time of Arrival: December 31
Solid
500 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
1 g	USD 80	In-stock	Estimated Time of Arrival: December 31
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Other Forms of Cyclamic acid:

Cyclamic Acid-d₁₁ In-stock
Cyclamic acid sodium In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Cyclamic acid (Cyclohexylsulfamic acid) is one of the most widely used artificial sweetenersin food and pharmaceuticals^[1].

Molecular Weight

179.24

Formula

C₆H₁₃NO₃S

CAS No.

100-88-9

Appearance

Solid

Color

White to off-white

SMILES

O=S(O)(NC1CCCCC1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

H₂O : ≥ 100 mg/mL (557.91 mM)

DMSO : 100 mg/mL (557.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.5791 mL	27.8956 mL	55.7911 mL
5 mM	1.1158 mL	5.5791 mL	11.1582 mL
10 mM	0.5579 mL	2.7896 mL	5.5791 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (13.95 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (13.95 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (249 KB) HNMR (239 KB)

Handling Instructions (2659 KB)

References

[1]. Leban I, et, al. Structures of artificial sweeteners--cyclamic acid and sodium cyclamate with other cyclamates. Acta Crystallogr B. 2007 Jun;63(Pt 3):418-25. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	5.5791 mL	27.8956 mL	55.7911 mL	139.4778 mL
	5 mM	1.1158 mL	5.5791 mL	11.1582 mL	27.8956 mL
	10 mM	0.5579 mL	2.7896 mL	5.5791 mL	13.9478 mL
	15 mM	0.3719 mL	1.8597 mL	3.7194 mL	9.2985 mL
	20 mM	0.2790 mL	1.3948 mL	2.7896 mL	6.9739 mL
	25 mM	0.2232 mL	1.1158 mL	2.2316 mL	5.5791 mL
	30 mM	0.1860 mL	0.9299 mL	1.8597 mL	4.6493 mL
	40 mM	0.1395 mL	0.6974 mL	1.3948 mL	3.4869 mL
	50 mM	0.1116 mL	0.5579 mL	1.1158 mL	2.7896 mL
	60 mM	0.0930 mL	0.4649 mL	0.9299 mL	2.3246 mL
	80 mM	0.0697 mL	0.3487 mL	0.6974 mL	1.7435 mL
	100 mM	0.0558 mL	0.2790 mL	0.5579 mL	1.3948 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Cyclamic acid Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclamic acid100-88-9Cyclohexylsulfamic acid CyclamateOthersartificialsweetenerInhibitorinhibitorinhibit

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