100-88-9
Chemical Structure
Cyclamic acid
Synonym(s): Cyclohexylsulfamic acid; Cyclamate
- CAS No.: 100-88-9
- Formula:C6H13NO3S
- Molecular Weight:179.24
IUPAC Name: cyclohexylsulfamic acid
InChIKey: HCAJEUSONLESMK-UHFFFAOYSA-N
SMILES: O=S(O)(NC1CCCCC1)=O
Biological Activity: Cyclamic acid (Cyclamate) is a commonly used sweetener. Cyclamic acid sodium is toxic to osteoblasts and can inhibit cell proliferation, induce apoptosis and reduce cell mineralization. Cyclamic acid sodium causes focal necrosis of bladder organs in rats in vitro, which can promote bladder cancer, but some studies have shown that low doses of Cyclamic acid sodium have no carcinogenic effect. In addition, Cyclamic acid sodium has no effect on insulin and glucagon secretion induced by arginine[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Cyclamic acid | 99.79% | Cyclamic acid (Cyclamate) is a commonly used sweetener. Cyclamic acid sodium is toxic to osteoblasts and can inhibit cell proliferation, induce apoptosis and reduce cell mineralization. Cyclamic acid sodium causes focal necrosis of bladder organs in rats in vitro, which can promote bladder cancer, but some studies have shown that low doses of Cyclamic acid sodium have no carcinogenic effect. In addition, Cyclamic acid sodium has no effect on insulin and glucagon secretion induced by arginine. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Cyclamic Acid-d11 | 99.90% | Cyclamic Acid-d11 is the deuterium labeled Cyclamic acid. Cyclamic acid (Cyclohexylsulfamic acid) is one of the most widely used artificial sweetenersin food and pharmaceuticals. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Leban I, et, al. Structures of artificial sweeteners--cyclamic acid and sodium cyclamate with other cyclamates. Acta Crystallogr B. 2007 Jun;63(Pt 3):418-25. [Content Brief]
- [2]. Chen Z, et al. Toxicity of food sweetener-sodium cyclamate on osteoblasts cells. Biochem Biophys Res Commun. 2019 Jan 8;508(2):507-511. [Content Brief]
- [3]. Bopp BA, et al. Toxicological aspects of cyclamate and cyclohexylamine. Crit Rev Toxicol. 1986;16(3):213-306. [Content Brief]
- [4]. Usami M, et al. Effect of cyclamate sodium, saccharin sodium and stevioside on arginine-induced insulin and glucagon secretion in the isolated perfused rat pancreas. Horm Metab Res. 1980 Dec;12(12):705-6. [Content Brief]
- [5]. Knowles MA, et al. Induction of morphological changes in the urothelium of cultured adult rat bladder by sodium saccharin and sodium cyclamate. Carcinogenesis. 1986 May;7(5):767-74. [Content Brief]
Keywords
