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  3. D-α-Tocopherol Succinate

D-α-Tocopherol Succinate (Synonyms: Vitamin E succinate)

Cat. No.: HY-131553
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D-α-Tocopherol Succinate (Vitamin E succinate) is an antioxidant tocopherol and a salt form of vitamin E. D-α-Tocopherol Succinate inhibits Cisplatin (HY-17394)-induced cytotoxicity. D-α-Tocopherol Succinate can be used for the research of cancer.

For research use only. We do not sell to patients.

D-α-Tocopherol Succinate Chemical Structure

D-α-Tocopherol Succinate Chemical Structure

CAS No. : 4345-03-3

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Description

D-α-Tocopherol Succinate (Vitamin E succinate) is an antioxidant tocopherol and a salt form of vitamin E. D-α-Tocopherol Succinate inhibits Cisplatin (HY-17394)-induced cytotoxicity. D-α-Tocopherol Succinate can be used for the research of cancer[1][2].

In Vitro

D-α-Tocopherol Succinate (1-20 μM; 24 hours) shows cytotoxicity to HEI-OC1 cells[1].
D-α-Tocopherol Succinate (10 μM; 48 hours) protects HEI-OC1 cells against cisplatin-induced ototoxicity and inhibits caspase-3 activity[1].
D-α-Tocopherol Succinate (0-50 μM; 18 hours) shows cytotoxicity to TC-1 tumor cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: HEI-OC1 cell line
Concentration: 1-20 μM
Incubation Time: 24 hours
Result: Significantly induced cytotoxicity at a concentration of 20 μM and showed a higher cytotoxicity potency compared with 10 μM.

Cell Viability Assay[1]

Cell Line: HEI-OC1 cell line
Concentration: 10 μM
Incubation Time: 48 hours
Result: Increased cisplatin-induced cell population. Inhibited cisplatin-induced necrotic, ROS production and late apoptosis. Decreased cleaved PARP and inhibited the expression of caspase-3 which related to cisplatin-induced apoptosis.

Cell Cytotoxicity Assay[2]

Cell Line: TC-1 tumor cells
Concentration: 0, 25 and 50 μM
Incubation Time: 18 hours
Result: Dose-dependently showed cytotoxic and induced a higher percentage of necrotic TC-1 cells as opposed to apoptotic cells.
In Vivo

D-α-Tocopherol Succinate (1-2 mg/kg; i.p. three times at 2 day intervals from TC-1 tumor cells injection for 10 days to 14 days) shows antitumor effects to mice with TC-1 tumor[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six- to eight-week-old female C57BL/6 mice with TC-1 tumor cells[2]
Dosage: 1 and 2 mg/kg
Administration: Intraperitoneal injection; 1 and 2 mg/kg three times at 2 day intervals; from TC-1 tumor cells injection for 10 days to 14 days
Result: Dreased the tumor volume, especially with a dose of 2 mg/kg.
Molecular Weight

530.78

Formula

C33H54O5

CAS No.
SMILES

CC1=C2C(CC[[email protected]](C)(O2)CCC[[email protected]](C)CCC[[email protected]](C)CCCC(C)C)=C(C(OC(CCC(O)=O)=O)=C1C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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D-α-Tocopherol Succinate
Cat. No.:
HY-131553
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