D-α-Tocopherol Succinate
Based on 3 publication(s) in Google Scholar
D-α-Tocopherol Succinate (Vitamin E succinate) is an antioxidant tocopherol and a salt form of vitamin E. D-α-Tocopherol Succinate inhibits Cisplatin (HY-17394)-induced cytotoxicity. D-α-Tocopherol Succinate can be used for the research of cancer.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 4345-03-3
- Formula: C33H54O5
- Molecular Weight:530.78
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) D-α-Tocopherol Succinate
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| 4T1 | IC50 |
10 μM
Compound: 1, VES
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Inhibition of mouse 4T1 cells adhesion to gelatinous matrix protein-coated surface after 60 mins by ELISA
Inhibition of mouse 4T1 cells adhesion to gelatinous matrix protein-coated surface after 60 mins by ELISA
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[PMID: 19708661] |
| HCT-116 | IC50 |
52.3 μM
Compound: alpha-TOS
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Cytotoxicity against Homo sapiens (human) HCT116 cells after 48 hr by SRB assay
Cytotoxicity against Homo sapiens (human) HCT116 cells after 48 hr by SRB assay
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10.1007/s00044-011-9801-3 |
| HepG2 | IC50 |
245 μM
Compound: alpha-TOS
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Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
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[PMID: 27344490] |
| HepG2 | IC50 |
55 μM
Compound: alpha-TOS
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Cytotoxicity against Homo sapiens (human) HepG2 cells after 48 hr by SRB assay
Cytotoxicity against Homo sapiens (human) HepG2 cells after 48 hr by SRB assay
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10.1007/s00044-011-9801-3 |
| MCF7 | IC50 |
>368 μM
Compound: alpha-TO-succinate
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Compound was tested for antiproliferative activity against human breast cancer cell line MCF-7 in MTT assay
Compound was tested for antiproliferative activity against human breast cancer cell line MCF-7 in MTT assay
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[PMID: 9873556] |
| MCF7 | IC50 |
57 μM
Compound: alpha-TOS
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Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
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[PMID: 27344490] |
| MT4 | IC50 |
66 μM
Compound: alpha-TOS
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Cytotoxicity against human MT4 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human MT4 cells assessed as reduction in cell viability after 72 hrs by MTT assay
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[PMID: 27344490] |
| RPMI-8226 | IC50 |
63 μM
Compound: alpha-TOS
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Cytotoxicity against human RPMI8226 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human RPMI8226 cells assessed as reduction in cell viability after 72 hrs by MTT assay
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[PMID: 27344490] |
| U-937 | IC50 |
113 μM
Compound: alpha-TOS
|
Cytotoxicity against human U937 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human U937 cells assessed as reduction in cell viability after 72 hrs by MTT assay
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[PMID: 27344490] |
D-α-Tocopherol Succinate (1-20 μM; 24 hours) shows cytotoxicity to HEI-OC1 cells[1]. D-α-Tocopherol Succinate (10 μM; 48 hours) protects HEI-OC1 cells against cisplatin-induced ototoxicity and inhibits caspase-3 activity[1]. D-α-Tocopherol Succinate (0-50 μM; 18 hours) shows cytotoxicity to TC-1 tumor cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEI-OC1 cell line
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Concentration:1-20 μM
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Incubation Time:24 hours
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Result:Significantly induced cytotoxicity at a concentration of 20 μM and showed a higher cytotoxicity potency compared with 10 μM.
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Cell Line:HEI-OC1 cell line
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Concentration:10 μM
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Incubation Time:48 hours
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Result:Increased cisplatin-induced cell population. Inhibited cisplatin-induced necrotic, ROS production and late apoptosis. Decreased cleaved PARP and inhibited the expression of caspase-3 which related to cisplatin-induced apoptosis.
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Cell Line:TC-1 tumor cells
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Concentration:0, 25 and 50 μM
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Incubation Time:18 hours
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Result:Dose-dependently showed cytotoxic and induced a higher percentage of necrotic TC-1 cells as opposed to apoptotic cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Six- to eight-week-old female C57BL/6 mice with TC-1 tumor cells[2]
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Dosage:1 and 2 mg/kg
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Administration:Intraperitoneal injection; 1 and 2 mg/kg three times at 2 day intervals; from TC-1 tumor cells injection for 10 days to 14 days
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Result:Dreased the tumor volume, especially with a dose of 2 mg/kg.
Chemical Information
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CAS No. 4345-03-3
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Appearance Solid
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Molecular Weight 530.78
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Formula C33H54O5
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Color White to off-white
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SMILES
CC1=C2C(CC[C@](C)(O2)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)=C(C(OC(CCC(O)=O)=O)=C1C)C
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Synonyms
Vitamin E succinate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (3)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
Donafenib and GSK-J4 Synergistically Induce Ferroptosis in Liver Cancer by Upregulating HMOX1 Expression. [Abstract]2023 Aug;10(22):e2206798. PMID: 37330650 -
Adv Healthc Mater
Cascade-Responsive Nanoprodrug Disrupts Immune-Fibroblast Communications for Potentiated Cancer Mechanoimmunotherapy. [Abstract]2025 Apr;14(11):e2500176. PMID: 40079115 -
Hum Reprod
Single-cell RNA sequencing reveals transcriptomic landscape and potential targets for human testicular ageing. [Abstract]2024 Oct 1;39(10):2189-2209. PMID: 39241251
Solvent & Solubility
DMSO : 250 mg/mL (471.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Kim SK, et al. The effects of the antioxidant α-tocopherol succinate on cisplatin-induced ototoxicity in HEI-OC1 auditory cells. Int J Pediatr Otorhinolaryngol. 2016 Jul;86:9-14. [Content Brief]
[2]. Kang TH, et al. Treatment of tumors with vitamin E suppresses myeloid derived suppressor cells and enhances CD8+ T cell-mediated antitumor effects. PLoS One. 2014 Jul 29;9(7):e103562. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8840 mL | 9.4201 mL | 18.8402 mL | 47.1005 mL |
| 5 mM | 0.3768 mL | 1.8840 mL | 3.7680 mL | 9.4201 mL | |
| 10 mM | 0.1884 mL | 0.9420 mL | 1.8840 mL | 4.7100 mL | |
| 15 mM | 0.1256 mL | 0.6280 mL | 1.2560 mL | 3.1400 mL | |
| 20 mM | 0.0942 mL | 0.4710 mL | 0.9420 mL | 2.3550 mL | |
| 25 mM | 0.0754 mL | 0.3768 mL | 0.7536 mL | 1.8840 mL | |
| 30 mM | 0.0628 mL | 0.3140 mL | 0.6280 mL | 1.5700 mL | |
| 40 mM | 0.0471 mL | 0.2355 mL | 0.4710 mL | 1.1775 mL | |
| 50 mM | 0.0377 mL | 0.1884 mL | 0.3768 mL | 0.9420 mL | |
| 60 mM | 0.0314 mL | 0.1570 mL | 0.3140 mL | 0.7850 mL | |
| 80 mM | 0.0236 mL | 0.1178 mL | 0.2355 mL | 0.5888 mL | |
| 100 mM | 0.0188 mL | 0.0942 mL | 0.1884 mL | 0.4710 mL |
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