Iloperidone hydrochloride
Based on 2 publication(s) in Google Scholar
Iloperidone hydrochloride (HP 873 hydrochloride) is a D2/5-HT2 receptor antagonist. Iloperidone hydrochloride is an atypical antipsychotic for the schizophrenia symptoms.
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- CAS. Nr.: 1299470-39-5
- Formel: C24H28ClFN2O4
- Molecular Weight:462.94
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Iloperidone hydrochloride
MoreAlle 5-HT Receptor Isoform-spezifische Produkte anzeigen
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Biologische Aktivität
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Rat D2 Receptor 54 nM (Ki) |
Rat 5-HT2 Receptor 3.1 nM (Ki) |
Rat D1 Receptor 546 nM (Ki) |
Rat 5-HT1A Receptor 168 nM (Ki) |
Rat 5-HT6 Receptor 42.7 nM (Ki) |
Rat 5-HT7 Receptor 21.6 nM (Ki) |
Human D1 Receptor 216 nM (Ki) |
Human D3 Receptor 7.1 nM (Ki) |
Human D4 Receptor 25 nM (Ki) |
Human D5 Receptor 319 nM (Ki) |
Human 5-HT2A Receptor 5.6 nM (Ki) |
Human 5-HT2C Receptor 42.8 nM (Ki) |
Iloperidone hydrochloride displays higher affinity for the dopamine D3 receptor (Ki=7.1 nM) than for the dopamine D4 receptor (Ki=25 nM). Iloperidone displays high affinity for the 5-HT6 and 5-HT7 receptors (Ki=42.7 and 21.6 nM, respectively), and is found to have higher affinity for the 5-HT2A (Ki=5.6 nM) than for the 5-HT2C receptor (Ki=42.8 nM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 1299470-39-5
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Molecular Weight 462.94
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Formel C24H28ClFN2O4
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SMILES
CC(C1=CC=C(OCCCN2CCC(C3=NOC4=C3C=CC(F)=C4)CC2)C(OC)=C1)=O.Cl
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Synonyms
HP 873 hydrochloride
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Neuroreport
2021 Nov 2;32(16):1299-1306. PMID: 34605450
Reinheit & Dokumentation
Verweise
[1]. Kongsamut, S., et al., Iloperidone binding to human and rat dopamine and 5-HT receptors. Eur J Pharmacol, 1996. 317(2-3): p. 417-23. [Content Brief]
[2]. Sainati, S.M., et al., Safety, tolerability, and effect of food on the pharmacokinetics of iloperidone (HP 873), a potential atypical antipsychotic. J Clin Pharmacol, 1995. 35(7): p. 713-20. [Content Brief]
[3]. Albers, L.J., A. Musenga, and M.A. Raggi, Iloperidone: a new benzisoxazole atypical antipsychotic drug. Is it novel enough to impact the crowded atypical antipsychotic market? Expert Opin Investig Drugs, 2008. 17(1): p. 61-75. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Iloperidone hydrochloride Related Classifications
HY-17410A Related Classifications
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