2. Others Antibody-drug Conjugate/ADC Related
  3. Isotope-Labeled Compounds Drug-Linker Conjugates for ADC
  4. Deruxtecan-d5

Deruxtecan-d5  (Synonyms: MC-GGFG-DXD-d5)

製品番号: HY-13631ES4 純度: 98.40%
COA 取扱説明書 Technical Support

Deruxtecan-d5 is deuterium labeled Deruxtecan (HY-13631E). Deruxtecan is an ADC drug-linker conjugate composed of an DX-8951 derivative (DXd) and a maleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402.

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Deruxtecan-d<sub>5</sub>

Deruxtecan-d5 構造式

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 2057 お問い合わせ 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks
Solution
10 mM * 1 mL in DMSO USD 2057 お問い合わせ 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks
Solid
1 mg $450 在庫あり
5 mg $1120 お問い合わせ 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks
10 mg $1800 お問い合わせ 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks
25 mg $3600 お問い合わせ 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks
50 mg $5760 お問い合わせ 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks
100 mg   お問い合わせ  
200 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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Other Forms of Deruxtecan-d5:

Deruxtecan-d5 関連抗体

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製品説明

Deruxtecan-d5 is deuterium labeled Deruxtecan (HY-13631E). Deruxtecan is an ADC drug-linker conjugate composed of an DX-8951 derivative (DXd) and a maleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402.

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

体外実験

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Deruxtecan-d5 関連抗体
分子量

1039.08

分子式

C52H51D5FN9O13
Unlabeled CAS
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C=CC1=O)N1CCCCCC(NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(NCC(NCOCC(N[C@@H]3C4=C5C(C(N6C5)=CC([C@](O)(C(OC7)=O)C([2H])([2H])C([2H])([2H])[2H])=C7C6=O)=NC8=CC(F)=C(C)C(CC3)=C84)=O)=O)=O)=O)=O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶剤 & 溶解度
体外: 

DMSO : ≥ 100 mg/mL (96.24 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9624 mL 4.8119 mL 9.6239 mL
5 mM 0.1925 mL 0.9624 mL 1.9248 mL
10 mM 0.0962 mL 0.4812 mL 0.9624 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9624 mL 4.8119 mL 9.6239 mL 24.0597 mL
5 mM 0.1925 mL 0.9624 mL 1.9248 mL 4.8119 mL
10 mM 0.0962 mL 0.4812 mL 0.9624 mL 2.4060 mL
15 mM 0.0642 mL 0.3208 mL 0.6416 mL 1.6040 mL
20 mM 0.0481 mL 0.2406 mL 0.4812 mL 1.2030 mL
25 mM 0.0385 mL 0.1925 mL 0.3850 mL 0.9624 mL
30 mM 0.0321 mL 0.1604 mL 0.3208 mL 0.8020 mL
40 mM 0.0241 mL 0.1203 mL 0.2406 mL 0.6015 mL
50 mM 0.0192 mL 0.0962 mL 0.1925 mL 0.4812 mL
60 mM 0.0160 mL 0.0802 mL 0.1604 mL 0.4010 mL
80 mM 0.0120 mL 0.0601 mL 0.1203 mL 0.3007 mL
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Deruxtecan-d5 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Deruxtecan-d5MC-GGFG-DXD-d5Isotope-Labeled CompoundsDrug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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製品名:
Deruxtecan-d5
製品番号:
HY-13631ES4
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