COX-2-IN-68
COX-2-IN-69 is a selective, orally active COX-2 inhibitor with an IC50 of 0.82 μM. COX-2-IN-69 occupies the secondary pocket of COX-2, interacts with His90 and Arg513, and reduces the serum levels of PGE2, IL-1β and TNF-α. COX-2-IN-69 exerts anti-inflammatory activity in a rat paw edema model. COX-2-IN-69 can be used in inflammation-related research.
For research use only. We do not sell to patients.
- Formula: C21H19BrN2O3
- Molecular Weight:427.29
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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COX-2 0.82 μM (IC50) |
IL-1β |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague Dawley (male, 130-150 g, Carrageenan (HY-125474)-induced paw edema model)[1]
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Dosage:10 mg/kg
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Administration:p.o.; single dose
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Result:Produced edema percentages of 17.58% at 1 h, 14.22% at 2 h, and 13.89% at 3 h post-Carrageenan injection.
Reduced serum PGE2 levels by 61.48% compared to the Carrageenan control group.
Reduced serum IL-1β levels by 62.17% compared to the carrageenan control group.
Reduced serum TNF-α levels by 58.36% compared to the carrageenan control group.
Showed moderate desquamation of gastric mucosa, inflammatory cell infiltration of the submucosa layer, and vacuolar degeneration of gastric glands, with milder gastric effects than indomethacin.
Chemical Information
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Molecular Weight 427.29
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Formula C21H19BrN2O3
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SMILES
CCOC1=C(O)C=CC(/C=C/C2=NNC(C(CC3=CC=C(Br)C=C3)=C2)=O)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
COX-2-IN-68 Related Classifications
HY-184709 Related Classifications
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