PDGFD - platelet derived growth factor D Gene

Also Known as IEGF; SCDGFB; MSTP036; SCDGF-B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 80310

About PDGFD

Cytogenetic location: 11q22.3 Genomic coordinates (GRCh38): 11:103,907,189-104,164,147 (from NCBI)

This gene has 3 transcripts (splice variants), 198 orthologues and 35 paralogues. Biased expression in adrenal (RPKM 66.8), ovary (RPKM 41.5) and 13 other tissues.

Summary

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does not dimerize with the Other three family members. It differs from alpha and beta members of this family in having an unusual N-terminal domain, the CUB domain. Two splice variants have been identified for this gene. [provided by RefSeq, Jul 2008]

PDGFD Products (2)

mRNA Protein Name
NM_025208.5 NP_079484.1 platelet-derived growth factor D isoform 1 precursor
NM_033135.4 NP_149126.1 platelet-derived growth factor D isoform 2 precursor

PDGFD Protein Structure

CUB

CUB: CUB domain (59 - 167)

PDGF

PDGF: PDGF/VEGF domain (272 - 362)

  • 0
  • 100
  • 200
  • 300
  • 370 a.a.
Protein Preferred Names Protein Names

platelet-derived growth factor D

  • PDGF-D

Recombinant PDGFD Proteins

Cat. No. Product Name Accession Purity
HY-P7280 PDGF-DD Protein, Human (CHO) Q9GZP0-1 (S250-R370) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Proliferative Glomerulonephritis
Obstructive Nephropathy

  • Con

  • Congenital Obstructive Nephropathy

  • Nephropathy Obstructive
Familiar Ovarian Carcinoma
Mesangial Proliferative Glomerulonephritis

  • Glomerulonephritis - Mesangial Proliferative

  • Mesangial Proliferative Gn

  • Mesangioproliferative Glomerulonephritis

  • Glomerulonephritis Mesangial Proliferative
Bronchiectasis 2
Brain Cancer

  • Adult Brain Tumor

  • Malignant Neoplasm Of Brain

  • Brain Neoplasms

  • Brain Neoplasm

  • Neoplasm Of Brain

  • Primary Malignant Neoplasm Of Brain

  • Brain Tumors

  • Adult Malignant Brain Neoplasm

  • Brain Neoplasm, Adult

  • Bt - Brain Tumour

  • Malignant Brain Tumour

  • Malignant Primary Brain Neoplasm

  • Malignant Primary Brain Tumor

  • Malignant Tumor Of Adult Brain

  • Malignant Tumor Of Brain

  • Primary Brain Neoplasm

  • Primary Brain Tumor

  • Tumor Of The Brain

  • Brain Tumor, Adult

  • Brain Tumor Primary

  • Malignant Primary Brain Tumors

  • Primary Brain Tumors

  • Cancer, Brain

  • Brain Tumor, Primary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10253 PDGFD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174550 Human PDGFD mRNA / Unkown
HY-RS18294 Pdgfd Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24772 Pdgfd Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PDGFD VGNC VGNC:44371
Mus musculus PDGFD MGD MGI:1919035
Felis catus PDGFD VGNC VGNC:64082
Rattus norvegicus PDGFD RGD RGD:621880
Macaca mulatta PDGFD VGNC VGNC:75900
Bos taurus PDGFD VGNC VGNC:32691
Others PDGFD NCBI