SLBP - stem-loop binding protein Gene

Also Known as HBP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7884

About SLBP

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:1,692,731-1,712,319 (from NCBI)

This gene has 6 transcripts (splice variants) and 203 orthologues. Ubiquitous expression in testis (RPKM 30.6), bone marrow (RPKM 27.2) and 25 other tissues.

Summary

This gene encodes a protein that binds to the stem-loop structure in replication-dependent histone mRNAs. Histone mRNAs do not contain introns or polyadenylation signals, and are processed by endonucleolytic cleavage. The stem-loop structure is essential for efficient processing but this structure also controls the transport, translation and stability of histone mRNAs. Expression of the protein is regulated during the cell cycle, increasing more than 10-fold during the latter part of G1. [provided by RefSeq, Jul 2008]

SLBP Products (3)

mRNA	Protein	Name
NM_001306074.2	NP_001293003.1	histone RNA hairpin-binding protein isoform 2
NM_001306075.2	NP_001293004.1	histone RNA hairpin-binding protein isoform 3
NM_006527.4	NP_006518.1	histone RNA hairpin-binding protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Referencias	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	23286197	GOA
enables mRNA binding	IDA IDA: Inferred from direct assay	16912046	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15829567	GOA

Biological Process GO Annotation	Evidence	Referencias	Source
involved in cap-dependent translational initiation	IDA IDA: Inferred from direct assay	18025107	GOA
involved in mRNA transport	IDA IDA: Inferred from direct assay	19155325	GOA

Cellular Component GO Annotation	Evidence	Referencias	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15829567	GOA
part of histone mRNA stem-loop binding complex	IPI IPI: Inferred from physical interaction	23286197	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15829567	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLBP Protein Structure

SLBP_RNA_bind

0
100
200
270 a.a.

Protein Preferred Names	Protein Names
histone RNA hairpin-binding protein	hairpin binding protein, histone

SLBP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Referencias
Intra	SLBP	Q14493	SLBP	Homo sapiens	Q14493	AFM	23286197
Intra	SLBP	Q14493	SLBP	Homo sapiens	Q14493	GMS	23286197
Intra	SLBP	Q14493	ERI1	Homo sapiens	Q8IV48	GMS	23329046
Intra	SLBP	Q14493	ERI1	Homo sapiens	Q8IV48	X-Ray Diffraction	23329046

Cross: Cross-species interaction Intra: Intraspecies interaction

SLBP Antibodies

Referencia número	Nombre del producto	Aplicación	Reactivity
HY-P82236	SLBP Antibody (YA1981)	WB, IHC-F, IHC-P, ICC/IF, IP	Human
HY-P82236A	SLBP Antibody (YA1981)(PBS only)	WB, IHC-F, IHC-P, ICC/IF, IP	Human

Related Diseases

Diseases	Alias
Wolf-Hirschhorn Syndrome	Pitt-Rogers-Danks Syndrome WHS Chromosome 4p16.3 Deletion Syndrome Wittwer Syndrome 4p- Syndrome Pitt Syndrome 4p Deletion Syndrome Distal Deletion 4p Distal Monosomy 4p Telomeric Deletion 4p Prds 4p Syndrome Chromosome 4p Syndrome Microcephaly, Iugr, Hypertelorism, Ptosis, Iris Coloboma, Hooked Nose, External Ear Dysplasia, Psychomotor Retardation Wolf Syndrome Chromosome 4p Deletion Syndrome Chromosome 4p Monosomy Del Syndrome Monosomy 4p Partial Monosomy 4p Chromosome 4 Short Arm Deletion
Chromosome 2q31.2 Deletion Syndrome
Blepharochalasis	Dermatolysis Palpebrarum Adiposa Ptosis
Epiphyseal Dysplasia, Multiple, 2	EDM2 Multiple Epiphyseal Dysplasia 2 Dysplasia, Epiphyseal, Multiple, Type 2
Multiple Epiphyseal Dysplasia Due To Collagen 9 Anomaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-RS12984	SLBP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SLBP	VGNC	VGNC:46210
Macaca mulatta	SLBP	VGNC	VGNC:77379
Rattus norvegicus	SLBP	RGD	RGD:1584682
Felis catus	SLBP	VGNC	VGNC:65179
Bos taurus	SLBP	VGNC	VGNC:34658
Mus musculus	SLBP	MGD	MGI:108402
Others	SLBP	NCBI