FSVVPSPK 

FSVVPSPK is an orally active peptide. FSVVPSPK exerts significant anti-adipogenic, antioxidant and anti-inflammatory effects in vitro and in vivo, mainly through activating the HO-1/Nrf2 pathway. FSVVPSPK can be used in research related to obesity and metabolic disorders^[1].

FSVVPSPK (10-100 μM; 48 h) exhibits no significant cytotoxicity against BMMSC cells, but inhibits intracellular reactive oxygen species (ROS) production^[1].
FSVVPSPK (10-100 μM; 7 days) inhibits adipogenic differentiation of BMMSCs by downregulating adipogenic transcription factors, suppressing lipogenic enzyme activity and enhancing lipolysis, with a maximum inhibitory rate of 55.72% on lipid accumulation after treatment at 100 μM for 7 days^[1].
FSVVPSPK (10-100 μM; 2-3 days) upregulates the expression of HO-1 in the cytoplasm and Nrf2 in the nucleus of BMMSCs^[1].
FSVVPSPK (10-100 μM; 7 days) inhibits the production of pro-inflammatory cytokines (IL-6, IL-1β, TNF-α) in BMMSCs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FSVVPSPK (1-10 mg/kg; p.o.; once daily; for 15 consecutive weeks) improves obesity, oxidative stress and inflammation in high-fat diet-induced obese mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

860.01

C₄₁H₆₅N₉O₁₁

2016043-82-4

Phe-Ser-Val-Val-Pro-Ser-Pro-Lys

FSVVPSPK

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Suryaningtyas IT, et al. Oral administration of PIISVYWK and FSVVPSPK peptides attenuates obesity, oxidative stress, and inflammation in high fat diet-induced obese mice. J Nutr Biochem. 2025;136:109791.  [Content Brief]