12S-HHT
Based on 1 publication(s) in Google Scholar
12S-HHT (12(S)-HHTrE) is an enzymatic product of prostaglandin H2 (PGH2) derived from cyclooxygenase (COX)-mediated arachidonic acid metabolism. 12S-HHT is an endogenous ligand for BLT2 that fully activates BLT2 in vivo. 12S-HHT suppresses UV-induced IL-6 synthesis in keratinocytes, exerting an anti-inflammatory activity.
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- Pureza: 98.4%
- No. CAS: 54397-84-1
- Fòrmula: C17H28O3
- Peso molecular:280.40
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Almacenamiento:
Solution, -20°C, 2 years
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Actividad biológica
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) 12S-HHT
MoreVer todos los productos específicos de isoformas Leukotriene Receptor
MoreVer todos los productos específicos de isoformas Endogenous Metabolite
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Actividad biológica
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Human Endogenous Metabolite |
BLT2 |
12S-HHT (0-150 nM; 3 hours) has anti-inflammatory activity by attenuating the UVB-induced IL-6 synthesis in HaCaT cells[2].
12S-HHT inhibits the UVB-stimulated p38 MAPK/NF-κB pathway by up-regulating MKP-1, which leads to the suppression of IL-6 synthesis[2].
12S-HHT is an endogenous agonist for BLT2[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HaCaT cells
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Concentration:0, 12.5, 25, 75 or 150 nM
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Incubation Time:3 hours
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Result:UVB (5 mJ/cm2) irradiation markedly up-regulated IL-6 synthesis and release, which was suppressed by the treatment with 12-HHT in a concentration-dependent manner.
Chemical Information
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No. CAS 54397-84-1
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Appearance Liquid
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Peso molecular 280.40
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Fòrmula C17H28O3
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Color Colorless to light yellow
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SMILES
CCCCC[C@H](O)/C=C/C=C/C/C=C\CCCC(O)=O
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Synonyms
12(S)-HHTrE
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Solution, -20°C, 2 years
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell Rep Med
2023 Jun 20;4(6):101061. PMID: 37267943
Pureza y Documentación
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Ficha de datos (267 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Saeki K, et al. Identification, signaling, and functions of LTB4 receptors. Semin Immunol. 2017;33:30-36. [Content Brief]
[2]. Lee JW, et al. 12(S)-Hydroxyheptadeca-5Z,8E,10E-trienoic acid suppresses UV-induced IL-6 synthesis in keratinocytes, exerting an anti-inflammatory activity. Exp Mol Med. 2012;44(6):378-386. [Content Brief]
[3]. Okuno T, et al. Metabolism and biological functions of 12(S)-hydroxyheptadeca-5Z,8E,10E-trienoic acid. Prostaglandins Other Lipid Mediat. 2021;152:106502. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
12S-HHT Related Classifications
HY-113330 Related Classifications
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