1. GPCR/G Protein
  2. Leukotriene Receptor
  3. LY223982

LY223982 (Synonyms: CGS23131; SKF107324)

Cat. No.: HY-112737 Purity: 100.00%
Handling Instructions

LY223982 is a potent and specific inhibitor of leukotriene B4 receptor, with an IC50 of 13.2 nM against [3H]LTB4 binding to LTB4 receptor.

For research use only. We do not sell to patients.

LY223982 Chemical Structure

LY223982 Chemical Structure

CAS No. : 117423-74-2

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5 mg USD 210 Get quote

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Description

LY223982 is a potent and specific inhibitor of leukotriene B4 receptor, with an IC50 of 13.2 nM against [3H]LTB4 binding to LTB4 receptor.

IC50 & Target[1]

LTB4

13.2 nM (IC50)

In Vitro

LY223982 is a potent and specific inhibitor of leukotriene B4 (LTB4) receptor, with an IC50 of 13.2 nM against [3H]LTB4 binding to LTB4 receptor. LY223982 is also a potent antagonist of the aggregation of human neutrophils by LTB4 (IC50, 100 nM)[1].

In Vivo

LY223982 inhibits transient leukopenia induced in rabbits with LTB4 (ED50, 3 mg/kg) but not with FMLP, and shows no agonist activity in any of the test systems[1].

Molecular Weight

502.56

Formula

C₃₀H₃₀O₇

CAS No.

117423-74-2

SMILES

O=C(O)CCC1=CC(C(C2=CC=CC(C(O)=O)=C2)=O)=CC=C1OCCCC/C=C/C3=CC=C(OC)C=C3

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (198.98 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9898 mL 9.9491 mL 19.8981 mL
5 mM 0.3980 mL 1.9898 mL 3.9796 mL
10 mM 0.1990 mL 0.9949 mL 1.9898 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.97 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (4.97 mM); Precipitated solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.97 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 100.00%

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LY223982
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HY-112737
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