1. GPCR/G Protein
  2. Leukotriene Receptor

LY223982 (Synonyms: CGS23131; SKF107324)

Cat. No.: HY-112737 Purity: 100.00%
Handling Instructions

LY223982 is a potent and specific inhibitor of leukotriene B4 receptor, with an IC50 of 13.2 nM against [3H]LTB4 binding to LTB4 receptor.

For research use only. We do not sell to patients.

LY223982 Chemical Structure

LY223982 Chemical Structure

CAS No. : 117423-74-2

Size Price Stock Quantity
1 mg USD 70 In-stock
Estimated Time of Arrival: December 31
5 mg USD 210 Get quote
10 mg   Get quote  
50 mg   Get quote  

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Customer Review

View All Leukotriene Receptor Isoform Specific Products:

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

LY223982 is a potent and specific inhibitor of leukotriene B4 receptor, with an IC50 of 13.2 nM against [3H]LTB4 binding to LTB4 receptor.

IC50 & Target[1]

LTB4

13.2 nM (IC50)

In Vitro

LY223982 is a potent and specific inhibitor of leukotriene B4 (LTB4) receptor, with an IC50 of 13.2 nM against [3H]LTB4 binding to LTB4 receptor. LY223982 is also a potent antagonist of the aggregation of human neutrophils by LTB4 (IC50, 100 nM)[1].

In Vivo

LY223982 inhibits transient leukopenia induced in rabbits with LTB4 (ED50, 3 mg/kg) but not with FMLP, and shows no agonist activity in any of the test systems[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9898 mL 9.9491 mL 19.8981 mL
5 mM 0.3980 mL 1.9898 mL 3.9796 mL
10 mM 0.1990 mL 0.9949 mL 1.9898 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

502.56

Formula

C₃₀H₃₀O₇

CAS No.

117423-74-2

SMILES

O=C(O)CCC1=CC(C(C2=CC=CC(C(O)=O)=C2)=O)=CC=C1OCCCC/C=C/C3=CC=C(OC)C=C3

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: 100.00%

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Product Name:
LY223982
Cat. No.:
HY-112737
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LY223982

Cat. No.: HY-112737