9(S)-HOTrE
Based on 1 Customer Validation
9(S)-HOTrE is a PPARα activator and an inducer of apolipoprotein A-I (apoA-I) mRNA expression. 9(S)-HOTrE upregulates the expression of PPARα target gene CPT1α. 9(S)-HOTrE can be used in the research of cardiovascular diseases.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.9%
- No. CAS: 89886-42-0
- Fòrmula: C18H30O3
- Peso molecular:294.43
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Almacenamiento:
Solution, -20°C, 2 years
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Actividad biológica
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Chemical Information
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Help & FAQs
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Actividad biológica
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CPT-1A |
PPARα |
9(S)-HOTrE (9 μg/mL; 16 h) potently activates the transcriptional activity of PPARα in HEK293 cells, and its activity at the concentration of 9 μg/mL is 11.6 times higher than that of the control group[1].
9(S)-HOTrE (10 μg/mL) activates PPARα in HepG2 cells, and at the concentration of 10 μg/mL, it increases the expression level of CPT1α mRNA by 8.0-fold compared with the control group[1].
9(S)-HOTrE (0.01-10 μg/mL) regulates the expression level of apoA-I mRNA in HepG2 cells[1].
9(S)-HOTrE (0.01-0.1 μg/mL) upregulates KEAP1 mRNA expression in HepG2 cells at concentrations that stimulate apoA-I transcription (0.01 μg/mL and 0.05 μg/mL), while it downregulates KEAP1 mRNA expression at the concentration of 0.1 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2 cells
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Concentration:0.01, 0.05, 0.1, 0.5, 1, 3, 5, 7, 8.3, 10 μg/mL
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Incubation Time:/
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Result:Increased apoA-I mRNA expression by 35% in HepG2 cells at an optimal concentration of 0.05 μg/mL, while reduced apoA-I mRNA expression at higher concentrations (≥3 μg/mL).
Chemical Information
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No. CAS 89886-42-0
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Appearance Liquid
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Peso molecular 294.43
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Fòrmula C18H30O3
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Color Colorless to light yellow
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SMILES
CC/C=C\C/C=C\C=C\[C@@H](O)CCCCCCCC(O)=O
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Solution, -20°C, 2 years
Pureza y Documentación
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Ficha de datos (265 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
9(S)-HOTrE Related Classifications
HY-113510 Related Classifications
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