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Referencia número: HY-N18878

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Ambigol C

Ambigol C is an ambigol, Antibacterial agent and Antimalarial agent. Ambigol C is isolated from Fischerella ambigua 108b. Ambigol C exhibits selective antibacterial activity against Gram-positive Staphylococcus aureus strains (including MRSA) with MIC values of 0.98-3.91 μg/mL. Ambigol C also shows potent antibacterial activity against B. megaterium, and possesses weak antimalarial and trypanocidal effects. Ambigol C can be used in the research of bacterial infections, plasmodial infections and trypanosomal infections.

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No. CAS: 850655-31-1
Fòrmula: C₁₈H₈Cl₆O₃
Peso molecular:484.97

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Ambigol C Chemical Structure

No. CAS: 850655-31-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Descripciòn

IC₅₀ & Target^[1]

Microbial Metabolite

Trypanosoma

Plasmodium

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Cellular Effect

Cell Line	Type	Value	Description	References
L6	MIC	100 μg/mL Compound: 1, ambigol C	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 15787461]

In Vitro

Ambigol C (24 h for antibacterial/antimycotic, 48 h for cytotoxicity) displays selective antibacterial activity against Gram-positive Staphylococcus aureus strains (including MRSA) with MIC values of 0.98-3.91 μg/mL, no activity against Escherichia coli or Candida albicans, and an IC₅₀ of 40 μg/mL against MRC-5 human lung fibroblasts^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 850655-31-1
Peso molecular 484.97
Fòrmula C₁₈H₈Cl₆O₃
SMILES

ClC1=CC=C(C(Cl)=C1)OC2=C(Cl)C(O)=C(Cl)C(OC3=CC=C(C=C3Cl)Cl)=C2
Structure Classification
- Phenols
- Monophenols
Initial Source
- Microorganisms
Fischerella ambigua
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Milzarek TM, et al. Antibiotic Potential of the Ambigol Cyanobacterial Natural Product Class and Simplified Synthetic Analogs. ACS Infect Dis. 2023;9(10):1941-1948. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Ambigol C

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Ambigol C Related Classifications

HY-N18878 Related Classifications