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Referencia número: HY-125984

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Syn-516

Syn-516 is an inhibitor of α-synuclein (α-Syn). Syn-516 targets the 5' untranslated region (5'UTR) of α-Syn mRNA, with an IC₅₀ value of 1.8 μM, thereby inhibiting the translation process of α-Syn. Syn-516 improves motor dysfunction and colonic motility abnormalities associated with α-Syn overexpression in mouse models. α-Syn can be used to study diseases such as Parkinson's disease and Lewy body dementia.

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No. CAS: 695209-67-7
Fòrmula: C₁₇H₁₇N₉S
Peso molecular:379.44

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Syn-516 Chemical Structure

No. CAS: 695209-67-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas α-synuclein :

Chemical Information

No. CAS 695209-67-7
Peso molecular 379.44
Fòrmula C₁₇H₁₇N₉S
SMILES

NC1=NC(CSC2=NN=NN2C3=C4C=CC=CC4=CC=C3)=NC(N(C)C)=N1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

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Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Cahill CM, et al. Alpha-synuclein in alcohol use disorder, connections with Parkinson’s disease and potential therapeutic role of 5’untranslated region-directed small molecules. Biomolecules. 2020 Oct 21;10(10):1465. [Content Brief]

[2]. Rogers JT, Cahill CM. Iron-responsive-like elements and neurodegenerative ferroptosis. Learning & Memory. 2020 Sep 1;27(9):395-413.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Syn-516

Ver todos los productos específicos de isoformas α-synuclein

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

Syn-516 Related Classifications

HY-125984 Related Classifications