695209-67-7
Chemical Structure
Syn-516
- CAS No.: 695209-67-7
- Formula:C17H17N9S
- Molecular Weight:379.44
IUPAC Name: N2,N2-dimethyl-6-(((1-(naphthalen-1-yl)-1H-tetrazol-5-yl)thio)methyl)-1,3,5-triazine-2,4-diamine
InChIKey: KEGAOGGMAQQKFO-UHFFFAOYSA-N
SMILES: NC1=NC(CSC2=NN=NN2C3=C4C=CC=CC4=CC=C3)=NC(N(C)C)=N1
Biological Activity: Syn-516 is an inhibitor of α-synuclein (α-Syn). Syn-516 targets the 5' untranslated region (5'UTR) of α-Syn mRNA, with an IC50 value of 1.8 μM, thereby inhibiting the translation process of α-Syn. Syn-516 improves motor dysfunction and colonic motility abnormalities associated with α-Syn overexpression in mouse models. α-Syn can be used to study diseases such as Parkinson's disease and Lewy body dementia[1][2].
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Syn-516 | Syn-516 is an inhibitor of α-synuclein (α-Syn). Syn-516 targets the 5' untranslated region (5'UTR) of α-Syn mRNA, with an IC50 value of 1.8 μM, thereby inhibiting the translation process of α-Syn. Syn-516 improves motor dysfunction and colonic motility abnormalities associated with α-Syn overexpression in mouse models. α-Syn can be used to study diseases such as Parkinson's disease and Lewy body dementia. | |||||||||||||||||||||
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References
- [1]. Cahill CM, et al. Alpha-synuclein in alcohol use disorder, connections with Parkinson’s disease and potential therapeutic role of 5’untranslated region-directed small molecules. Biomolecules. 2020 Oct 21;10(10):1465. [Content Brief]
- [2]. Rogers JT, Cahill CM. Iron-responsive-like elements and neurodegenerative ferroptosis. Learning & Memory. 2020 Sep 1;27(9):395-413.
