ZLWT-37
ZLWT-37 is a potent, orally active CDKs inhibitor with IC50 values of 0.002 μM and 0.054 μM against CDK9 and CDK2, respectively. ZLWT-37 induces apoptosis and arrests the cell cycle in the G2/M phase in HCT116 cells.
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- No. CAS: 2813347-44-1
- Fòrmula: C26H30ClN5O
- Peso molecular:464.00
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
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CDK9 0.002 μM (IC50) |
CDK2 0.054 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | GI50 |
0.051 μM
Compound: ZLWT-37
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Antiproliferative activity against human A549 cells assessed as cell growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as cell growth inhibition after 72 hrs by MTT assay
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[PMID: 36054949] |
| HCT-116 | GI50 |
0.029 μM
Compound: ZLWT-37
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Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition after 72 hrs by MTT assay
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[PMID: 36054949] |
| MCF7 | GI50 |
0.109 μM
Compound: ZLWT-37
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Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition after 72 hrs by MTT assay
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[PMID: 36054949] |
| SW480 | GI50 |
0.328 μM
Compound: ZLWT-37
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Antiproliferative activity against human SW480 cells assessed as cell growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against human SW480 cells assessed as cell growth inhibition after 72 hrs by MTT assay
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[PMID: 36054949] |
ZLWT-37 shows antiproliferative activity with a GI50 of 0.029 μM for HCT116[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2813347-44-1
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Peso molecular 464.00
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Fòrmula C26H30ClN5O
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SMILES
N[C@H]1CCN(C1)C2=C3CCCCC3=NC4=C2C=C(C=C4)C5=CC=NC(NC(C6CC6)=O)=C5.Cl
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ZLWT-37 Related Classifications
HY-147771 Related Classifications
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