Chrna5 - cholinergic receptor, nicotinic, alpha polypeptide 5 Gene

Also Known as Acra5; Acra-5

Species: Mus musculus

Gene Type: protein coding
Gene ID: 110835

Summary

Predicted to enable acetylcholine binding activity and acetylcholine-gated cation-selective channel activity. Predicted to contribute to acetylcholine receptor activity. Involved in regulation of synaptic vesicle exocytosis. Acts upstream of or within response to nicotine. Located in dopaminergic synapse. Part of acetylcholine-gated channel complex. Is expressed in gut; lung; nervous system; and thymus. Human ortholog(s) of this gene implicated in lung Cancer. Orthologous to human CHRNA5 (cholinergic receptor nicotinic alpha 5 subunit). [provided by Alliance of Genome Resources, Apr 2022]

Chrna5 Products (3)

mRNA Protein Name
NM_001373901.1 NP_001360830.1 neuronal acetylcholine receptor subunit alpha-5 isoform 1 precursor
NM_001373902.1 NP_001360831.1 neuronal acetylcholine receptor subunit alpha-5 isoform 3 precursor
NM_176844.5 NP_789814.2 neuronal acetylcholine receptor subunit alpha-5 isoform 2

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in presynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
19693710 MGI
involved in presynaptic modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
19693710 MGI
involved in regulation of postsynaptic neurotransmitter receptor activity IDA
IDA: Inferred from direct assay
32817066 MGI
involved in regulation of postsynaptic neurotransmitter receptor activity IMP
IMP: Inferred from mutant phenotype
32817066 MGI
acts upstream of or within response to nicotine IMP
IMP: Inferred from mutant phenotype
9495872 MGI
Cellular Component GO Annotation Evidence References Source
part of acetylcholine-gated channel complex IPI
IPI: Inferred from physical interaction
17434683 MGI
is active in cholinergic synapse IDA
IDA: Inferred from direct assay
32817066 MGI
is active in cholinergic synapse IMP
IMP: Inferred from mutant phenotype
32817066 MGI
is active in dopaminergic synapse IDA
IDA: Inferred from direct assay
19693710 MGI
is active in dopaminergic synapse IMP
IMP: Inferred from mutant phenotype
19693710 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neuronal acetylcholine receptor subunit alpha-5

  • nicotinic acetylcholine receptor alpha5 subunit

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS19054 Chrna5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02670 CHRNA5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25544 Chrna5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Chrna5 NCBI NCBI:1138