Slc5a5 - solute carrier family 5 (sodium iodide symporter), member 5 Gene

Mus musculus

Also known as NIS

Gene ID: 114479 | Gene type: protein coding

About Slc5a5

Summary

Enables sodium:iodide symporter activity. Predicted to be involved in iodide transmembrane transport and sodium ion transport. Predicted to act upstream of or within ion transport. Predicted to be located in nucleus. Predicted to be active in plasma membrane. Is expressed in axial skeleton tail region; stomach; testis; and thyroid gland. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 1. Orthologous to human SLC5A5 (solute carrier family 5 member 5). [provided by Alliance of Genome Resources, Apr 2022]

Slc5a5 Products(1)

mRNA	Protein	Name
NM_053248.2	NP_444478.2	sodium/iodide cotransporter

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables sodium:iodide symporter activity	IDA IDA: Inferred from direct assay	11431151	MGI
enables symporter activity	IDA IDA: Inferred from direct assay	11431151	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	18372236	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	18372236	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

sodium/iodide cotransporter

Na(+)/I(-) cotransporter	Na(+)/I(-) symporter
sodium-iodide symporter	solute carrier family 5 member 5

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13291	SLC5A5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc5a5	NCBI	NCBI:6528

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