Slc5a5 - solute carrier family 5 (sodium iodide symporter), member 5 Gene

Also Known as NIS

Species: Mus musculus

Gene Type: protein coding
Gene ID: 114479

Summary

Enables sodium:iodide symporter activity. Predicted to be involved in iodide transmembrane transport and sodium ion transport. Predicted to act upstream of or within ion transport. Predicted to be located in nucleus. Predicted to be active in plasma membrane. Is expressed in axial skeleton tail region; stomach; testis; and thyroid gland. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 1. Orthologous to human SLC5A5 (solute carrier family 5 member 5). [provided by Alliance of Genome Resources, Apr 2022]

Slc5a5 Products (1)

mRNA Protein Name
NM_053248.2 NP_444478.2 sodium/iodide cotransporter

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables sodium:iodide symporter activity IDA
IDA: Inferred from direct assay
11431151 MGI
enables symporter activity IDA
IDA: Inferred from direct assay
11431151 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
18372236 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
18372236 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sodium/iodide cotransporter

  • Na(+)/I(-) cotransporter

  • Na(+)/I(-) symporter

  • sodium-iodide symporter

  • solute carrier family 5 member 5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13291 SLC5A5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc5a5 NCBI NCBI:6528