SORCS1 - sortilin related VPS10 domain containing receptor 1 Gene

Also Known as hSorCS

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 114815

About SORCS1

Cytogenetic location: 10q25.1 Genomic coordinates (GRCh38): 10:106,573,663-107,181,138 (from NCBI)

This gene has 10 transcripts (splice variants), 425 orthologues and 4 paralogues. Broad expression in thyroid (RPKM 5.3), brain (RPKM 3.7) and 16 other tissues.

Summary

This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing Receptor Proteins. The VPS10 domain name comes from the yeast Carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system. Two of the five family members (sortilin and sortilin-related receptor) are synthesized as preproproteins; it is not yet known if this encoded protein is also a preproprotein. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

SORCS1 Products (7)

mRNA Protein Name
NM_001013031.3 NP_001013049.1 VPS10 domain-containing receptor SorCS1 isoform b precursor
NM_001206569.2 NP_001193498.1 VPS10 domain-containing receptor SorCS1 isoform c precursor
NM_001206570.2 NP_001193499.1 VPS10 domain-containing receptor SorCS1 isoform d precursor
NM_001206571.2 NP_001193500.1 VPS10 domain-containing receptor SorCS1 isoform e precursor
NM_001206572.2 NP_001193501.1 VPS10 domain-containing receptor SorCS1 isoform f precursor
NM_001387556.1 NP_001374485.1 VPS10 domain-containing receptor SorCS1 isoform g precursor
NM_052918.5 NP_443150.3 VPS10 domain-containing receptor SorCS1 isoform a precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12482870 GOA
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
12482870 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SORCS1 Protein Structure

PKD

PKD: PKD domain (808 - 880)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1168 a.a.
Protein Preferred Names Protein Names

VPS10 domain-containing receptor SorCS1

  • VPS10 domain receptor protein SORCS 1

Recombinant SORCS1 Proteins

Cat. No. Product Name Accession Purity
HY-P76650 SorCS1 Protein, Human (HEK293, His) Q8WY21 (S111-S1099) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Alzheimer Disease 6

  • Ad6

  • Alzheimer Disease 6, Late-Onset

  • Alzheimer'S Disease 6

  • Alzheimer Disease 6, Late Onset
Alacrima, Achalasia, And Mental Retardation Syndrome

  • AAMR

  • Alacrima, Achalasia, And Intellectual Disability Syndrome

  • Alacrima, Achalasia, And Impaired Intellectual Development Syndrome

  • Intellectual Disability
Narcolepsy

  • Paroxysmal Sleep

  • Gelineau Syndrome

  • Narcoleptic Syndrome

  • Narcolepsy-Cataplexy Syndrome

  • Cataplexy And Narcolepsy

  • Narcolepsy, Without Cataplexy

  • Gelineau'S Syndrome

  • Narcolepsy With Or Without Cataplexy

  • Narcolepsy Nos
Parkinson Disease, Late-Onset

  • Parkinson Disease

  • Parkinson'S Disease

  • PD

  • PARK

  • Parkinson Disease, Susceptibility To

  • Late Onset Parkinson'S Disease

  • Late Onset Parkinson Disease

  • Paralysis Agitans

  • Primary Parkinsonism

  • Idiopathic Parkinson Disease

  • Parkinson'S

  • Parkinson Disease, Late-Onset, Susceptibility To

  • Parkinson Disease, Age Of Onset, Modifier

  • Lewy Body Parkinson Disease

  • Idiopathic Parkinson'S Disease

  • Pd - [Parkinson Disease]

  • Parkinson Disease Nos

  • Parkinson, Nos

  • Primary Parkinson Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13570 SORCS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19814 Sorcs1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26310 Sorcs1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SORCS1 VGNC VGNC:77724
Rattus norvegicus SORCS1 RGD RGD:1305910
Felis catus SORCS1 VGNC VGNC:65571
Canis familiaris SORCS1 VGNC VGNC:46659
Mus musculus SORCS1 MGD MGI:1929666
Bos taurus SORCS1 VGNC VGNC:35130
Others SORCS1 NCBI