Aldh1a2 - aldehyde dehydrogenase 1 family, member A2 Gene

Rattus norvegicus

Also known as Raldh-2

Gene ID: 116676 | Gene type: protein coding

About Aldh1a2

Summary

Enables retinal binding activity and retinal dehydrogenase activity. Involved in several processes, including gland development; response to vitamin A; and retinoic acid biosynthetic process. Located in cytosol and perinuclear region of cytoplasm. Orthologous to human ALDH1A2 (aldehyde dehydrogenase 1 family member A2). [provided by Alliance of Genome Resources, Apr 2022]

Aldh1a2 Products(1)

mRNA	Protein	Name
NM_053896.2	NP_446348.2	retinal dehydrogenase 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables retinal binding	IDA IDA: Inferred from direct assay	8663198	RGD
enables retinal dehydrogenase activity	IDA IDA: Inferred from direct assay	12547725	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in kidney development	IEP IEP: Inferred from expression pattern	15567713	RGD
involved in liver development	IEP IEP: Inferred from expression pattern	14729401	RGD
involved in midgut development	IEP IEP: Inferred from expression pattern	15964596	RGD
involved in pituitary gland development	IEP IEP: Inferred from expression pattern	17180597	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	15205379	RGD
involved in response to vitamin A	IEP IEP: Inferred from expression pattern	11169459	RGD
involved in retinoic acid biosynthetic process	IEP IEP: Inferred from expression pattern	15950969	RGD
involved in retinoic acid biosynthetic process	IMP IMP: Inferred from mutant phenotype	21138835	RGD
involved in retinoic acid metabolic process	IDA IDA: Inferred from direct assay	12547725	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	21138835	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

retinal dehydrogenase 2

RALDH 2	RalDH(II)
aldehyde dehydrogenase 1A2	aldehyde dehydrogenase family 1 member A2
aldehyde dehydrogenase family 1, subfamily A2	ralDH2
retinal dehydrogenase, type II	retinaldehyde-specific dehydrogenase type 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W011094	Win 18446	Inhibitor	98.94%	Unkown
HY-122912	ALDH1A inhibitor 673A		99.15%	Unkown
HY-125085	ALDH3A1-IN-3	Inhibitor	99.43%	Unkown
HY-135841	CM010	Inhibitor	99.70%	Unkown
HY-139031	ALDH1A2-IN-1	Inhibitor	98.05%	Unkown
HY-139032	CM121	Inhibitor	/	Unkown
HY-157567	FSI-TN42	Inhibitor	98.05%	Unkown
HY-128299	ALDH3A1-IN-4	Inhibitor	/	Unkown
HY-158026	ALDH1A1-IN-5	Inhibitor	/	Unkown
HY-N11451	Lacto-N-fucopentaose III	Activator	96.54%	Unkown
HY-RS00561	Aldh1a1 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS00563	ALDH1A2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00567	ALDH1L2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17028	Aldh1a2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23472	Aldh1a2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Aldh1a2	NCBI	NCBI:8854

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