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Aspm - abnormal spindle microtubule assembly Gene

Also Known as Sha1; MCPH5; Calmbp1; D330028K02Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 12316

Summary

Enables Calmodulin binding activity. Involved in regulation of meiotic cell cycle. Acts upstream of or within several processes, including gamete generation; maintenance of centrosome location; and nervous system development. Located in cytoplasm; microtubule cytoskeleton; and midbody. Is expressed in several structures, including gonad; gut; hemolymphoid system gland; nervous system; and perichondrium. Used to study microcephaly. Human ortholog(s) of this gene implicated in microcephaly; primary autosomal recessive microcephaly; primary autosomal recessive microcephaly 5; and visual epilepsy. Orthologous to human ASPM (assembly factor for spindle microtubules). [provided by Alliance of Genome Resources, Apr 2022]

Aspm Products (1)

mRNA	Protein	Name
NM_009791.4	NP_033921.3	abnormal spindle-like microcephaly-associated protein homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calmodulin binding	IDA IDA: Inferred from direct assay	23152892	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of asymmetric cell division	IMP IMP: Inferred from mutant phenotype	16798874	MGI
acts upstream of or within brain development	IMP IMP: Inferred from mutant phenotype	20823249	MGI
acts upstream of or within cerebral cortex development	IMP IMP: Inferred from mutant phenotype	24220505	MGI
acts upstream of or within developmental growth	IMP IMP: Inferred from mutant phenotype	20823249	MGI
acts upstream of or within forebrain neuroblast division	IMP IMP: Inferred from mutant phenotype	16798874	MGI
acts upstream of or within maintenance of centrosome location	IMP IMP: Inferred from mutant phenotype	16798874	MGI
acts upstream of or within male gonad development	IMP IMP: Inferred from mutant phenotype	24220505	MGI
acts upstream of or within meiotic spindle assembly	IMP IMP: Inferred from mutant phenotype	23152892	MGI
acts upstream of or within negative regulation of asymmetric cell division	IMP IMP: Inferred from mutant phenotype	16798874	MGI
acts upstream of or within negative regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	16798874	MGI
acts upstream of neuroblast proliferation	IGI IGI: Inferred from genetic interaction	21937711	MGI
acts upstream of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	21937711	MGI
acts upstream of or within neuron migration	IGI IGI: Inferred from genetic interaction	21937711	MGI
acts upstream of or within neuron migration	IMP IMP: Inferred from mutant phenotype	21937711	MGI
acts upstream of or within neuronal stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	19896444	MGI
acts upstream of or within oogenesis	IMP IMP: Inferred from mutant phenotype	20823249	MGI
acts upstream of or within positive regulation of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	21937711	MGI
acts upstream of or within positive regulation of neuroblast proliferation	IGI IGI: Inferred from genetic interaction	21937711	MGI
acts upstream of or within positive regulation of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	21937711	MGI
involved in regulation of meiotic cell cycle	IMP IMP: Inferred from mutant phenotype	23152892	MGI
acts upstream of or within spermatogenesis	IMP IMP: Inferred from mutant phenotype	20823249	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	23152892	MGI
located in meiotic spindle	IDA IDA: Inferred from direct assay	23152892	MGI
located in microtubule	IDA IDA: Inferred from direct assay	23152892	MGI
located in midbody	IDA IDA: Inferred from direct assay	20823249	MGI
located in mitotic spindle pole	IDA IDA: Inferred from direct assay	22031545	MGI
located in spindle pole	IDA IDA: Inferred from direct assay	16798874	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
abnormal spindle-like microcephaly-associated protein homolog	asp (abnormal spindle)-like, microcephaly associated calmodulin-binding protein 1 calmodulin-binding protein Sha1 spindle and hydroxyurea checkpoint abnormal protein

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01104	ASPM Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21296	Aspm Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27815	Aspm Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Aspm	NCBI	NCBI:259266