Gli3 - GLI-Kruppel family member GLI3 Gene

Also Known as Xt; Bph; Pdn; add; GLI3FL; GLI3-190

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14634

Summary

Enables DNA-binding transcription factor activity; chromatin binding activity; and sequence-specific DNA binding activity. Involved in several processes, including negative thymic T cell selection; regulation of alpha-beta T cell differentiation; and thymocyte apoptotic process. Acts upstream of or within several processes, including animal organ development; nervous system development; and positive regulation of cell differentiation. Located in axoneme and nuclear speck. Part of transcription repressor complex. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; genitourinary system; and sensory organ. Used to study Greig cephalopolysyndactyly syndrome and Pallister-Hall syndrome. Human ortholog(s) of this gene implicated in Greig cephalopolysyndactyly syndrome; Pallister-Hall syndrome; anodontia; polydactyly; and syndactyly. Orthologous to human GLI3 (Gli family zinc finger 3). [provided by Alliance of Genome Resources, Apr 2022]

Gli3 Products (1)

mRNA Protein Name
NM_008130.3 NP_032156.2 transcriptional activator GLI3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
11053430 MGI
enables chromatin binding IGI
IGI: Inferred from genetic interaction
16396903 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10920228 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
16611981 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within T cell differentiation in thymus IMP
IMP: Inferred from mutant phenotype
15855276 MGI
involved in T cell differentiation in thymus IMP
IMP: Inferred from mutant phenotype
15855276 MGI
acts upstream of or within alpha-beta T cell differentiation IMP
IMP: Inferred from mutant phenotype
15855276 MGI
acts upstream of or within anatomical structure development IGI
IGI: Inferred from genetic interaction
11485934 MGI
acts upstream of or within anatomical structure formation involved in morphogenesis IGI
IGI: Inferred from genetic interaction
9731531 MGI
acts upstream of or within anterior semicircular canal development IMP
IMP: Inferred from mutant phenotype
17395647 MGI
acts upstream of or within anterior/posterior pattern specification IGI
IGI: Inferred from genetic interaction
22841643 MGI
acts upstream of or within anterior/posterior pattern specification IMP
IMP: Inferred from mutant phenotype
15315762 MGI
acts upstream of apoptotic process IMP
IMP: Inferred from mutant phenotype
19048639 MGI
acts upstream of or within artery development IGI
IGI: Inferred from genetic interaction
16968815 MGI
acts upstream of or within axon guidance IMP
IMP: Inferred from mutant phenotype
15065125 MGI
acts upstream of or within brain development IMP
IMP: Inferred from mutant phenotype
8026071 MGI
acts upstream of or within branching involved in ureteric bud morphogenesis IGI
IGI: Inferred from genetic interaction
16396903 MGI
acts upstream of or within branching morphogenesis of an epithelial tube IMP
IMP: Inferred from mutant phenotype
16247775 MGI
acts upstream of or within camera-type eye development IGI
IGI: Inferred from genetic interaction
18582859 MGI
acts upstream of or within camera-type eye morphogenesis IMP
IMP: Inferred from mutant phenotype
8387379 MGI
acts upstream of or within cell differentiation involved in kidney development IGI
IGI: Inferred from genetic interaction
19809516 MGI
acts upstream of cell population proliferation IGI
IGI: Inferred from genetic interaction
16396903 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
16396903 MGI
acts upstream of or within central nervous system development IGI
IGI: Inferred from genetic interaction
12435628 MGI
acts upstream of or within central nervous system development IMP
IMP: Inferred from mutant phenotype
12435629 MGI
acts upstream of or within cerebral cortex radial glia-guided migration IMP
IMP: Inferred from mutant phenotype
9232833 MGI
acts upstream of chondrocyte differentiation IGI
IGI: Inferred from genetic interaction
16284117 MGI
acts upstream of or within developmental growth IMP
IMP: Inferred from mutant phenotype
9268579 MGI
acts upstream of or within dorsal/ventral pattern formation IMP
IMP: Inferred from mutant phenotype
12435629 MGI
acts upstream of or within embryonic digestive tract development IMP
IMP: Inferred from mutant phenotype
10693670 MGI
acts upstream of or within embryonic digestive tract morphogenesis IMP
IMP: Inferred from mutant phenotype
16247775 MGI
acts upstream of or within embryonic digit morphogenesis IGI
IGI: Inferred from genetic interaction
9268572 MGI
acts upstream of or within embryonic digit morphogenesis IMP
IMP: Inferred from mutant phenotype
9268572 MGI
acts upstream of or within embryonic limb morphogenesis IGI
IGI: Inferred from genetic interaction
16284117 MGI
acts upstream of or within embryonic limb morphogenesis IMP
IMP: Inferred from mutant phenotype
8387379 MGI
acts upstream of or within embryonic morphogenesis IMP
IMP: Inferred from mutant phenotype
8387379 MGI
acts upstream of or within embryonic neurocranium morphogenesis IMP
IMP: Inferred from mutant phenotype
27395007 MGI
acts upstream of or within embryonic skeletal system morphogenesis IGI
IGI: Inferred from genetic interaction
15728667 MGI
acts upstream of or within forebrain development IMP
IMP: Inferred from mutant phenotype
16168404 MGI
acts upstream of or within forebrain dorsal/ventral pattern formation IMP
IMP: Inferred from mutant phenotype
10625551 MGI
acts upstream of or within forebrain radial glial cell differentiation IMP
IMP: Inferred from mutant phenotype
9232833 MGI
acts upstream of or within frontal suture morphogenesis IMP
IMP: Inferred from mutant phenotype
20570969 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
23201751 MGI
acts upstream of or within heart development IGI
IGI: Inferred from genetic interaction
11172440 MGI
acts upstream of or within hindgut morphogenesis IGI
IGI: Inferred from genetic interaction
11485934 MGI
acts upstream of or within hippocampus development IMP
IMP: Inferred from mutant phenotype
22235033 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
16254602 MGI
acts upstream of or within inner ear development IGI
IGI: Inferred from genetic interaction
17395647 MGI
acts upstream of or within kidney development IGI
IGI: Inferred from genetic interaction
11172440 MGI
acts upstream of or within lambdoid suture morphogenesis IMP
IMP: Inferred from mutant phenotype
20570969 MGI
acts upstream of or within larynx morphogenesis IMP
IMP: Inferred from mutant phenotype
28177282 MGI
acts upstream of or within lateral ganglionic eminence cell proliferation IMP
IMP: Inferred from mutant phenotype
20943929 MGI
acts upstream of or within lateral semicircular canal development IMP
IMP: Inferred from mutant phenotype
17395647 MGI
acts upstream of or within layer formation in cerebral cortex IMP
IMP: Inferred from mutant phenotype
21525285 MGI
involved in limb development IMP
IMP: Inferred from mutant phenotype
17400206 MGI
acts upstream of or within limb morphogenesis IMP
IMP: Inferred from mutant phenotype
9268572 MGI
acts upstream of or within lung development IGI
IGI: Inferred from genetic interaction
15136151 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
9268579 MGI
acts upstream of or within mammary gland development IMP
IMP: Inferred from mutant phenotype
16914490 MGI
acts upstream of or within mammary gland specification IGI
IGI: Inferred from genetic interaction
16720875 MGI
acts upstream of or within melanocyte differentiation IMP
IMP: Inferred from mutant phenotype
18397875 MGI
acts upstream of or within metanephros development IGI
IGI: Inferred from genetic interaction
16396903 MGI
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12435627 MGI
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
17400206 MGI
involved in negative regulation of alpha-beta T cell differentiation IMP
IMP: Inferred from mutant phenotype
19667090 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
19048639 MGI
acts upstream of or within negative regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
16396903 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
16396903 MGI
acts upstream of or within negative regulation of chondrocyte differentiation IGI
IGI: Inferred from genetic interaction
16284117 MGI
acts upstream of or within negative regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
19048639 MGI
involved in negative regulation of smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
19667090 MGI
acts upstream of or within negative regulation of stem cell proliferation IGI
IGI: Inferred from genetic interaction
20570969 MGI
acts upstream of or within negative regulation of stem cell proliferation IMP
IMP: Inferred from mutant phenotype
20570969 MGI
involved in negative thymic T cell selection IMP
IMP: Inferred from mutant phenotype
19667090 MGI
acts upstream of or within neural tube development IMP
IMP: Inferred from mutant phenotype
8387379 MGI
acts upstream of neuroblast proliferation IMP
IMP: Inferred from mutant phenotype
20943929 MGI
acts upstream of or within neuroblast proliferation IMP
IMP: Inferred from mutant phenotype
20943929 MGI
acts upstream of neuron differentiation IMP
IMP: Inferred from mutant phenotype
19048639 MGI
acts upstream of or within neuron fate commitment IMP
IMP: Inferred from mutant phenotype
16168404 MGI
acts upstream of or within odontogenesis of dentin-containing tooth IGI
IGI: Inferred from genetic interaction
9655803 MGI
acts upstream of or within oligodendrocyte differentiation IGI
IGI: Inferred from genetic interaction
15880651 MGI
acts upstream of or within optic nerve morphogenesis IMP
IMP: Inferred from mutant phenotype
16342201 MGI
acts upstream of osteoblast differentiation IGI
IGI: Inferred from genetic interaction
20570969 MGI
acts upstream of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
20570969 MGI
acts upstream of or within pallium development IMP
IMP: Inferred from mutant phenotype
10409502 MGI
acts upstream of or within pattern specification process IGI
IGI: Inferred from genetic interaction
14602680 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
17328886 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11053430 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
17400206 MGI
involved in positive regulation of alpha-beta T cell differentiation IMP
IMP: Inferred from mutant phenotype
15855276 MGI
acts upstream of or within positive regulation of chondrocyte differentiation IMP
IMP: Inferred from mutant phenotype
17328886 MGI
acts upstream of or within positive regulation of neuroblast proliferation IMP
IMP: Inferred from mutant phenotype
20943929 MGI
acts upstream of or within positive regulation of osteoblast differentiation IGI
IGI: Inferred from genetic interaction
20570969 MGI
acts upstream of or within positive regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
20570969 MGI
acts upstream of or within positive regulation of protein import into nucleus IGI
IGI: Inferred from genetic interaction
17043310 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
19667090 MGI
acts upstream of protein import into nucleus IGI
IGI: Inferred from genetic interaction
17043310 MGI
acts upstream of or within protein processing IDA
IDA: Inferred from direct assay
19036983 MGI
acts upstream of or within proximal/distal pattern formation IGI
IGI: Inferred from genetic interaction
16342201 MGI
acts upstream of or within proximal/distal pattern formation IMP
IMP: Inferred from mutant phenotype
16342201 MGI
acts upstream of or within regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
9152009 MGI
acts upstream of or within regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
8026071 MGI
acts upstream of or within regulation of bone development IMP
IMP: Inferred from mutant phenotype
22841643 MGI
acts upstream of or within regulation of cell differentiation IGI
IGI: Inferred from genetic interaction
16284117 MGI
acts upstream of or within regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
17191253 MGI
acts upstream of or within regulation of gene expression IGI
IGI: Inferred from genetic interaction
18799682 MGI
acts upstream of or within regulation of smoothened signaling pathway IGI
IGI: Inferred from genetic interaction
28817564 MGI
acts upstream of or within roof of mouth development IMP
IMP: Inferred from mutant phenotype
18816854 MGI
acts upstream of or within sagittal suture morphogenesis IMP
IMP: Inferred from mutant phenotype
20570969 MGI
acts upstream of or within smoothened signaling pathway IGI
IGI: Inferred from genetic interaction
12435628 MGI
involved in smoothened signaling pathway IGI
IGI: Inferred from genetic interaction
22234993 MGI
acts upstream of or within smoothened signaling pathway involved in dorsal/ventral neural tube patterning IGI
IGI: Inferred from genetic interaction
17395647 MGI
acts upstream of or within smoothened signaling pathway involved in spinal cord motor neuron cell fate specification IGI
IGI: Inferred from genetic interaction
15215207 MGI
acts upstream of or within smoothened signaling pathway involved in ventral spinal cord interneuron specification IGI
IGI: Inferred from genetic interaction
15215207 MGI
acts upstream of or within spinal cord dorsal/ventral patterning IGI
IGI: Inferred from genetic interaction
15215207 MGI
acts upstream of or within spinal cord motor neuron differentiation IGI
IGI: Inferred from genetic interaction
21552265 MGI
acts upstream of stem cell proliferation IGI
IGI: Inferred from genetic interaction
20570969 MGI
acts upstream of stem cell proliferation IMP
IMP: Inferred from mutant phenotype
20570969 MGI
acts upstream of or within subpallium development IMP
IMP: Inferred from mutant phenotype
20943929 MGI
acts upstream of or within telencephalon development IMP
IMP: Inferred from mutant phenotype
10625551 MGI
involved in thymocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
19667090 MGI
acts upstream of or within tongue development IMP
IMP: Inferred from mutant phenotype
18816854 MGI
acts upstream of or within tube development IGI
IGI: Inferred from genetic interaction
9731531 MGI
acts upstream of or within vocalization behavior IMP
IMP: Inferred from mutant phenotype
28177282 MGI
Cellular Component GO Annotation Evidence References Source
located in axoneme IDA
IDA: Inferred from direct assay
21209331 MGI
is active in cilium IDA
IDA: Inferred from direct assay
27046536 MGI
located in cilium IDA
IDA: Inferred from direct assay
19684112 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
12435627 MGI
located in nuclear speck IDA
IDA: Inferred from direct assay
19684112 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12435627 MGI
part of transcription repressor complex IDA
IDA: Inferred from direct assay
12435627 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcriptional activator GLI3

  • GLI3 form of 190 kDa

  • GLI3 full length protein

  • anterior digit pattern deformity

  • brachyphalangy

  • extra toes

  • polydactyly Nagoya

  • zinc finger protein GLI3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05476 GLI3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05482 GLIS3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21349 Gli3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27868 Gli3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29495 Glis3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gli3 NCBI NCBI:2737