Nqo1 - NAD(P)H dehydrogenase, quinone 1 Gene

Also Known as Dtd; Ox1; Qr1; Dia4; Nmo1; Ox-1; Nmo-1; Nmor1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18104

Summary

Enables NAD(P)H dehydrogenase (quinone) activity. Acts upstream of or within negative regulation of catalytic activity and response to oxidative stress. Predicted to be located in cytoplasm; dendrite; and neuronal cell body. Predicted to be active in cytosol. Is expressed in heart; main olfactory bulb; olfactory epithelium; and skin. Human ortholog(s) of this gene implicated in several diseases, including asthma; hematologic Cancer (multiple); lung disease (multiple); macular degeneration; and small cell carcinoma. Orthologous to human NQO1 (NAD(P)H quinone dehydrogenase 1). [provided by Alliance of Genome Resources, Apr 2022]

Nqo1 Products (1)

mRNA Protein Name
NM_008706.5 NP_032732.3 NAD(P)H dehydrogenase [quinone] 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables NAD(P)H dehydrogenase (quinone) activity IDA
IDA: Inferred from direct assay
1914521 MGI
enables NADH:ubiquinone reductase (non-electrogenic) activity IDA
IDA: Inferred from direct assay
8999809 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
29934320 MGI
Biological Process GO Annotation Evidence References Source
involved in cytokine production IMP
IMP: Inferred from mutant phenotype
29934320 MGI
involved in innate immune response IMP
IMP: Inferred from mutant phenotype
29934320 MGI
acts upstream of or within negative regulation of catalytic activity IDA
IDA: Inferred from direct assay
10903442 MGI
involved in protein catabolic process IDA
IDA: Inferred from direct assay
29934320 MGI
involved in protein polyubiquitination IDA
IDA: Inferred from direct assay
29934320 MGI
involved in response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
29934320 MGI
acts upstream of or within response to oxidative stress IMP
IMP: Inferred from mutant phenotype
15386390 MGI
involved in vitamin K metabolic process IDA
IDA: Inferred from direct assay
8999809 MGI
Cellular Component GO Annotation Evidence References Source
is active in cytoplasm IDA
IDA: Inferred from direct assay
29934320 MGI
is active in nucleus IDA
IDA: Inferred from direct assay
29934320 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

NAD(P)H dehydrogenase [quinone] 1

  • DT-diaphorase

  • NAD(P)H dehydrogenase (quinone)

  • NAD(P)H menadione oxidoreductase 1, dioxin inducible

  • NAD(P)H:quinone oxidoreductase 1

  • azoreductase

  • diaphorase 4 (NADH/NADPH)

  • menadione reductase

  • phylloquinone reductase

  • quinone reductase 1

Recombinant Nqo1 Proteins

Cat. No. Product Name Accession Purity
HY-P71831 Azoreductase/NQO1 Protein, Mouse (P.pastoris, His) Q64669 (A2-K274) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-141439 TBE 31 Inducer / Unkown
HY-181017 Ola-NC-SS-PEG-Lap / Unkown
HY-D3209 NIR-ASM / Unkown
HY-170947 Antitumor agent-195 Inhibitor / Unkown
HY-180155 Keap1/Nrf2/ARE activator 2 Activator / Unkown
HY-183692 FXR agonist 18 Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nqo1 NCBI NCBI:1728